Sudha

Fe(II) complexes [Fe(mqs)(B)2](PF6)(1)-(3) of  2-thiol 4-methylquinoline and phenanthroline bases (B), viz 1,10-Phenanthroline (phen in 1), Dipyrido[3,2-d:2',3'-f]quinoxaline (dpq in 2) and Dipyrido[3,2-a:2′,3′-c]phenazine (dppz in 3) have been prepared and characterized. The DNA-binding behaviors of these three complexes were investigated by absorption spectra, viscosity measurements and thermal denaturation studies. The DNA-binding constants for complexes 1, 2 and 3 were determined to 2.4 x104, 1.3 x 105 and 4.2 x105 M-1, respectively. The experimental results suggest that these complexes interact with DNA through groove binding mode. The photo induced cleavage studies shows that the complexes possess photonuclease property against pUC19 DNA under UV–Visible irradiation via a mechanistic pathway involving formation of singlet oxygen as the reactive species. Antibacterial PDT for E. coli strain, the control group showed a significantly higher (p0.05) in the CFU counts. The complex (3)/Light group presented a significant decrease in the CFU counts (p

A pestle and mortar-assisted solvent-free condensation of salicylaldehyde and 2-aminopyridine efficiently afforded a NO donor Schiff base ligand in high yield. This is an environmentally benign method, as satisfactory results were obtained in solvent free conditions with excellent yields, short reaction time, and operational simplicity in the experimental procedure. Copper(II) complex of this ligand were synthesized. Schiff base ligand and its complex were characterized by their melting point, elemental analysis, IR and 1H NMR spectra. In addition, DNA-binding properties of the metal complex were investigated using absorption spectroscopy, viscosity measurements and thermal denaturation methods. The DNA photoclevage experiment shows that, the complex act as effective DNA cleavage agent.

Solvent extraction of iron (III) from hydrochloric, sulphuric, nitric and perchloric acid solutions with Tri-n-butylamine (TBuA) in benzene has been studied. The extractions are nearly quantitative from all the acid solutions. The optimum conditions for extraction were established from the study of the effect of several variables like concentration of amine, metal ion, acidity, foreign ions etc. Attempts are also made to strip iron from the organic phase with 1.0M H2SO4. The extracted species are identified.  The method has been applied for the determination of iron in tap water as well as ferrochrome slag.

In the current status there is no explicit demarcation methodology on finding of substitutes (Pratinidhi Dravya). Thus here an attempt has been made to find out substitute by DNA fingerprinting on the basis of similarity and dissimilarity. In this study two samples Alysicarpus longifolius W. & A.Prodr.- Fabaceae, Desmodium laxiflorum DC i.e. of same family, same genus with different species were subjected to fingerprints. In this data we find a more similarities characteristics in both the plants i.e. up to 63%. As per the knowledge of research scientist this is a first moral attempt which throwing lights on concept of Pratinidhi Dravya (Substitution) in Ayurvedic science.

Over the past 30 years greater attention has been focused on development of sustained or controlled release drug delivery. MEMS has been identified as one of the most promising technologies for the 21st century and has the potential to revolutionalize both industrial and consumer products by combining silicon based microelectronics with micromachining technology. MEMS based drug delivery devices have become commercially feasible due to converging technologies and regulatory accommodation. These products have the potential to completely control drug release, meeting requirements for on-demand pulsatile or adjustable continuous administration for extended periods. MEMS technology involves integration of mechanical elements, sensors, actuators and electronic elements on common silicon substrate through microfabrication technology.

The pivotal motif of the present research work is to develop immediate release tablets of Fexofenadine hydrochloride. The rate of dissolution and bioavailability of the Fexofenadine HCL may be increased by using superdisintegrant in its immediate release tablets. Direct compression method was adapted to prepare the tablets by using lactose, microcrystalline cellulose as filler, crospovidone and sodium starch glycolate as superdisintegrant in different concentration (2-8%). Tablet were prepared and evaluated for Hardness, friability, weight variation, content uniformity, wetting time, disintegration time and in-vitro drug release. Disintegration time decreased with increase in the level of crospovidone. Whereas, disintegration time increased with increase in the level of sodium starch glycolate. The results indicate that the selected batch of tablet formulation containing crospovidone provides DT between 3-6 minutes with sufficient crushing strength and accepted friability. It was concluded that immediate release tablet for Fexofenadine hydrochloride can be formulated for fast treatment of allergic rhinitis

An efficient and rapid synthesis of some new pyrazoles, isoxazole, benzoxazepine and benzothiazepine derivatives is described. The synthesized compounds were investigated for their anti-inflammatory and antimicrobial activities and some of them showed potent anti-inflammatory and anti-microbial activities.

There is a growing demand for herbal cosmetics in the world market and they are invaluable gifts of nature. Therefore, the basic intention of the present study was to design a proper formulation contain the flower extract of Butea monosperma (FEBM) with improved physical parameter. To accomplish this intention the herbal gel was prepared and subjected to evaluation of the various parameters. The cosmetic gel formulation was designed by using ethanolic extract of FEBM in varied concentration (0.5, 1 and 1.5%) using carbapol 940 as gelling agent and evaluated for various parameters. The study was also undertaken to evaluate the stability of gels. The prepared gels were evaluated for various physicochemical parameters such as physical observation, homogeneity, pH determination, viscosity, spreadability, extrudability, drug content, rate of drug permeability, stability as per ICH guidelines and HPTLC fingerprint profiles. All developed gels showed good homogeneity with absence of lumps. All gels were found to be stable with respective to their pH, viscosity and drug content. The extrudability and spreadability were also found to be less variant after stability study. The gels of Butea monosperma are radically permeable from skin of rats as demonstrate by the in-vitro permeation study. However, further preclinical studies of gel need to evaluate further confirming the reported biological activities. There is also need to evaluate effects especially in human phase, would be beneficial to assess its usefulness more exactly.

In traditional medicine, there are many natural crude drugs that have the potential to treat many disease and disorders, one of them is Butea monosperma (Lam.) Taub (Syn. Butea frondosa; Family Fabaceae) popularly known as 'palas', and commonly known as ‘Flame of forest’. Butea monosperma is a tree of tropical and subtropical climate found throughout the drier parts of India, often gregarious in forests, open grasslands and wastelands. It grows on a wide variety of soils including shallow, gravelly sites, black cotton soil, clay loams, and even saline or waterlogged soils. It is an erect, medium sized tree of 12-15 m high, with a crooked trunk and irregular branches. There are various species of Butea monosperma available over the world. The leaves 3 foliate, large and stipulate. Number of constituents belonging to imides, lactones, flavonoids, sterols, and alkaloids has been reported from various species of Butea. Butea monosperma is considered as a good source for products such as fodder, fuel, fibre, timber, gum or resin, dyestuff and traditionally in number of ailments. Pharmacologically Butea monosperma has been reported for various activities such as anthelmintic, anticonceptive, anticonvulsive, antidiabetic, antidiarrhoeal, antiestrogenic and antifertility, antiinflammatory, antimicrobial, antifungal, antibacterial, antistress, chemopreventive, haemaggultinating, hepatoprotective, radical scavenging, thyroid inhibitory, antiperoxidative and hypoglycemic effects and wound healing activities. The present review discusses the morphology, ethanobotany, phytochemical constituents, and traditional uses of each part of plants as well products of plant and pharmacological activities of each part of plant in details.

  The purpose of the present study was to develop an optimized gastric floating extended release matrix tablet of Metformin hydrochloride (FERMTs) using a hydrophilic polymer, HPMC K4M, a hydrophobic polymer ethyl cellulose and sodium bicarbonate as buoyancy contributor. The formulation of FERMTs were designed by D-optimal mixture design taking % of HPMC K4M, ethyl cellulose and sodium bicarbonate as formulation variables and prepared by wet granulation method. The FERMTs were then evaluated for hardness, friability, weight variation, content uniformity, in vitro drug release and floating capacity. Finally, the floating lag time (FLT) and cumulative % drug release at 1h, 2h, 6h and 10h were taken as response variables and the FERMT formulation was numerically optimized by D-optimal mixture design using Design-Expert software (version 8.1). The optimized formula showed excellent floating efficiency over 10 h period with FLT of 9.61 mins. The release profile of optimized formula showed much closed similarity with that of USP reference dissolution profile (f2 value= 87.95). Analysis of dissolution data showed that the kinetic of drug release followed Korsemeyer-Peppas and Higuchi model.