physicochemical properties

Co-crystallization is an emerging approach for enhancing physicochemical properties like solubility, stability, bioavailability of poorly soluble drugs of BCS class II in pharmaceutical development without changing the chemical composition and considered better alternatives to optimize drug properties. Co-crystal is a crystalline entity consists of API and a stoichiometric amount of a pharmaceutically acceptable co-crystal former formed by intermolecular interactions like Hydrogen bonding, π-π stacking and Van der Waals forces. In this article, an overview of pharmaceutical cocrystals will be presented along with the intermolecular interactions (Chemistry of Co-crystals), methods of their preparations, characterization of co-crystals altered physicochemical properties. Furthermore, this article also gives a brief explanation about newer trends in co-crystals with application of co-crystals in medicines and industries.

There is a growing demand for herbal cosmetics in the world market and they are invaluable gifts of nature. Therefore, the basic intention of the present study was to design a proper formulation contain the flower extract of Butea monosperma (FEBM) with improved physical parameter. To accomplish this intention the herbal gel was prepared and subjected to evaluation of the various parameters. The cosmetic gel formulation was designed by using ethanolic extract of FEBM in varied concentration (0.5, 1 and 1.5%) using carbapol 940 as gelling agent and evaluated for various parameters. The study was also undertaken to evaluate the stability of gels. The prepared gels were evaluated for various physicochemical parameters such as physical observation, homogeneity, pH determination, viscosity, spreadability, extrudability, drug content, rate of drug permeability, stability as per ICH guidelines and HPTLC fingerprint profiles. All developed gels showed good homogeneity with absence of lumps. All gels were found to be stable with respective to their pH, viscosity and drug content. The extrudability and spreadability were also found to be less variant after stability study. The gels of Butea monosperma are radically permeable from skin of rats as demonstrate by the in-vitro permeation study. However, further preclinical studies of gel need to evaluate further confirming the reported biological activities. There is also need to evaluate effects especially in human phase, would be beneficial to assess its usefulness more exactly.