Pyrazole

The various methods of synthesizing pyrazole and bipyrazole moieties have always been a subject of interest for medicinal chemists. Primarily, the pyrazoles have been synthesized from diketones, hydrazones, acetylenes and more recently from chalcones. The bipyrazoles in turn have been derived from pyrazoles. The important methods of synthesis including the recent techniques have been reported in this review.

An efficient and rapid synthesis of some new pyrazoles, isoxazole, benzoxazepine and benzothiazepine derivatives is described. The synthesized compounds were investigated for their anti-inflammatory and antimicrobial activities and some of them showed potent anti-inflammatory and anti-microbial activities.