Anti-inflammatory activity

Vateria indica Linn (sarja) is one of the plant species that cultivated near the Western Ghats, On critically analyzing the status of Vateria indica Linn. It have  carminative and digestant activity. It is used as the oral medicament for treatment of various disease but it was found to be over exploited & highly felled for the purpose of making plywood. The current study was performed for anti-inflammatory activity of the Vateria indica leaves . Extraction of dried materials were performed with the help of successive solvents extraction(SSE) with the help of soxhlet apparatus. The anti-inflammatory of Vateria indica leaves were performed according to the guideline of World Health Organization (WHO). The anti-inflammatory activity of the Vateria indica extracts showed may be due to presence alkaloids, carbohydrates, steroids and glycosides. 3 Keywords- Extraction, Anti-inflammatory activity, Vateria indica Linn

Schleicheraoleosa is (Lour.) Oken belonging to the family Sapindaceae. An ethanolic extract of Schleicheraoleosa bark was investigated for its Anti-nociceptic and anti-inflammatory activities in rats and mice. Anti-nociceptic  activity was evaluated  by using the tail immersion, tail flick and hot plate latency assay while the anti-inflammatory test were carried out using the carrageenan induced paw oedema model in rats. Pentazocin was used for analgesic activity and Indomethacin was used for anti-inflammatory activities as standard drugs. The in tail immersion, tail flick and the hot plate latency times were increased with the increase in  doses of 200, 400 & 600 mg/kg significantly. . Similarly, for the carrageenan induced paw oedema model the result show that the extracts at the doses of 200, 400 & 600 mg/kg significantly (P < 0.001) inhibited the paw oedema in a dose dependent manner. The present study proved that the ethanolic extract of S. oleosa has analgesic and anti-inflammatory activities property.

The present study investigates the anti-inflammatory activity in ethanolic extract of Canthium Parviflorum using carrageenan induced paw edema in albino rats. The medicinal values of the Canthium Parviflorum have been mentioned ancient literature as useful in disorders of inflammation. Dried leaves of Canthium Parviflorum powdered and extracted with ethanol using soxhlet apparatus. The anti-inflammatory activity was done by carrageenan induced hind paw edema method using plethys mometer. Diclofenac is used as a standard drug. The significant inhibitory activity shown by the leaf extract of Canthium Parviflorum (125, 250, and 375 mg/kg) over a period of 4h in carragenan-induced inflammation was quite similar to that exhibited by the group treated with diclofenac sodium. The highest percentage inhibition activity was found in the dose of 375 mg/kg with the mean percentage inhibition of 23.45% after 4 hours of extract administration.

Barleria gibsoni belonging to the family Acanthaceae is commonly known as Neel Koranti.  Several species of Barleria are reported for treatment of inflammation associated diseases like Gout, Rheumatism and swelling etc. So, the present work has been taken for phytochemical screening and to investigate anti-inflammatory activity. Anti-inflammatory activity was done by Carrageenan induced hind paw edema method using a plethysmometer. Ibuprofen was used as a standard drug and control receives saline. The test groups received 200 mg/kg and 400 mg/kg of Ethanolic extract of Barleria gibsoni. Phytochemical screening of EEBG revealed the presence of phytocontituents like carbohydrates, tannins and flavonoids. In acute oral toxicity study it was observed that there was no mortality at any doses up to 2 mg/kg. The EEBG shows significant anti-inflammatory activity in carrageenan induced rats.

The present investigation has been undertaken with aim to formulation and evaluation of etoricoxib gel with different gelling agent and different penetration enhancer. Etoricoxib is highly selective cyclooxygenase-2 (COX-2) inhibitor. In this present study gel with carbopol, HPMC and Na-CMC as gelling agent prepared with different penetration enhancer like propyl glycol, oleic acid. Menthol oil. Formulation were evaluated for pH, stability study, spreadibilty, extrudabilty, bioadhesive (ex-vivo), skin irritation, viscosity, appearance and In-vitro drug diffusion. The formulation of Etoricoxib topical gel was prepared using carbopol, HPMC and Na-cmc in three batches A, B and C. With the consideration of all formulation characteristic and parameter we selected batch-A formulation for further study of anti-inflammatory and anti-analgesic activity. It was concluded that the Etoricoxib gel formulation containing carbopol with increase concentration of propyl glycol 10% and 2% oleic acid (OA) was suitable for topical application and it shows comparable result with market product and shows much better result of formulation, anti-inflammatory and anti-analgesic activity.

An efficient and rapid synthesis of some new pyrazoles, isoxazole, benzoxazepine and benzothiazepine derivatives is described. The synthesized compounds were investigated for their anti-inflammatory and antimicrobial activities and some of them showed potent anti-inflammatory and anti-microbial activities.