Sodium CMC

The present investigation has been undertaken with aim to formulation and evaluation of etoricoxib gel with different gelling agent and different penetration enhancer. Etoricoxib is highly selective cyclooxygenase-2 (COX-2) inhibitor. In this present study gel with carbopol, HPMC and Na-CMC as gelling agent prepared with different penetration enhancer like propyl glycol, oleic acid. Menthol oil. Formulation were evaluated for pH, stability study, spreadibilty, extrudabilty, bioadhesive (ex-vivo), skin irritation, viscosity, appearance and In-vitro drug diffusion. The formulation of Etoricoxib topical gel was prepared using carbopol, HPMC and Na-cmc in three batches A, B and C. With the consideration of all formulation characteristic and parameter we selected batch-A formulation for further study of anti-inflammatory and anti-analgesic activity. It was concluded that the Etoricoxib gel formulation containing carbopol with increase concentration of propyl glycol 10% and 2% oleic acid (OA) was suitable for topical application and it shows comparable result with market product and shows much better result of formulation, anti-inflammatory and anti-analgesic activity.

Herbal medicine has become an integral part of standard healthcare based on combination of traditional usage and on-going scientific research. Gel is a semisolid system consisting of dispersion made up of either small inorganic particles or large organic molecules enclosing an interpenetrated liquid. The inorganic particles form a three dimensional structure. The gel formulation was designed by using ethanolic extract of Cassia tora seeds and evaluated for various physiological measurements; preparation involved various concentration combinations of Carbopol 934 and Sodium CMC. Containing 1.55%of Cassia tora extract, Glycerin, Methyl paraben, Propyl paraben and required amount of distilled water and neutralized by drop wise addition of tri-ethanolamine to get gel like consistency. The results of physiochemical parameters of formulations were pH (6.8 to 6.89), viscosity, spreadability, extrudability, in-vitro release respectively. Concentration and combination effect of Carbopol 934 and Sodium CMC showed increased consistency and sustained action with increase in concentration.

The objective of this research work was to prepare sustained release matrix tablets of doxofylline. Doxofylline is a  xanthine bronchodilator having reduced affinity for A1 & A2 adenosine receptors. Different grades of hydrophilic polymers( HPMC K4M, HPMC K15 cps, HPMC K100 M, Sodium carboxymethylcellulose) and hydrophobic polymer (ethyl cellulose) were used. FTIR study shows that drug and other excipients are compatible with each other. Tablets were prepared by wet granulation technique using non-aqueous solvent IPA and PVP K90D as a binder. Under stage I of preliminary study, tablets were formulated using polymers alone. In stage II polymers were used in combination, with an objective of sustaining release up to 12 hrs. The effect polymer concentration on drug release profile was  investigated. The amounts of HPMC K100 M & NaCMC were selected as independent variables. The results of  final batches indicated that a low concentration of HPMC K100 M & high amount of Sodium CMC favours sustained release of doxofylline from matrix tablets. Accelerated stability study for 8 weeks  confirmed that the best selected formulation F 15 was stable