Cassia tora

Inflammation plays key role in various diseases such as asthma, atherosclerosis and rheumatoid arthritis. Inflammation is defined as the local response of living mammalian tissues to tissue injury due to any agent. It is a body defense reaction in order to eliminate or limit the spread of injurious agent as well as to remove the consequent necrosed cells and tissues. Leucas aspera is a used orally as stimulant, anthelmintic, laxative, diaphoretic, for the treatment of headache, asthma, and bronchitis. The decoction of roots, stem of Leucas aspera is used orally for high fevers, for influenza, and for malarial fevers. Cassia tora commonly is used as tonic, carminative and stimulant. According to Ayurveda the leaves and seeds are acrid, laxative, antiperiodic, anthelmintic, ophthalmic, liver tonic, cardiotonic and expectorant. This study was aimed to evaluation of anti-inflammatory activity of the roots of Leucas aspera and Cassia tora.

Herbal medicine has become an integral part of standard healthcare based on combination of traditional usage and on-going scientific research. Gel is a semisolid system consisting of dispersion made up of either small inorganic particles or large organic molecules enclosing an interpenetrated liquid. The inorganic particles form a three dimensional structure. The gel formulation was designed by using ethanolic extract of Cassia tora seeds and evaluated for various physiological measurements; preparation involved various concentration combinations of Carbopol 934 and Sodium CMC. Containing 1.55%of Cassia tora extract, Glycerin, Methyl paraben, Propyl paraben and required amount of distilled water and neutralized by drop wise addition of tri-ethanolamine to get gel like consistency. The results of physiochemical parameters of formulations were pH (6.8 to 6.89), viscosity, spreadability, extrudability, in-vitro release respectively. Concentration and combination effect of Carbopol 934 and Sodium CMC showed increased consistency and sustained action with increase in concentration.