Sudha

Hypertension (HT) is a very common disorder, particularly for past middle age. It is not a disease in itself, but is an important risk factor for cardiovascular mortality and morbidity. For improved treatment of hypertension, Telmisartan and Benidipine HCl is the newer combination in market, this combination was developed to improve medication for Stage II hypertension. The aim of this review is to focus on comprehensive update of different analytical methods used for estimation of anti-hypertensive drugs like Telmisartan and Benidipine HCl for the treatment of hypertension. This review delivers a detail description on different analytical methods like UV and RP-HPLC for Telmisartan and Benidipine HCl individually and combination with other drugs. For this review, data searches were conducted by scientific papers in the literature as well as in official compendium. All reported methods are found to be simple, accurate, economic, precise and reproducible in nature.

Bronchiolitis is a common lung infection in young children and infants. It causes inflammation and congestion in the small airways (bronchioles) of the lung. Bronchiolitis is almost caused by a virus. Bronchodilators are medication which makes breathing easier by relaxing the muscles in the lungs and widening airways. To assess the efficacy and risk associated with the use of bronchodilators in pediatric patients with bronchiolitis.  To assess the Efficacy of Bronchodilators, to evaluate the risk associated with bronchodilators in bronchiolitis patients and to evaluate the patient compliance in patients using bronchodilator for bronchiolitis. This study was conducted in 10 bronchiolitic pediatric patients. This study was conducted by categorizing the patients according to their Respiratory Rate, SpO2 and Heart Rate values. Patient compliance is analyzed using CRS scale and risk is assessed with Wang Scale.

The present paper investigated the In-vitro anthelmintic activity of ethanolic extracts of Mollugo nudicaulis Lam, Syzygium cumini Linn and Hibiscus vitifolius Linn to determine the possible effects by using Pheretima Posthuma (Indian adult earthworm). Two concentrations of each extracts (50,100mg/ml) were used in this activity and the same concentration of Albendazole as a standard drug and distilled water with 1%w/v carboxyl methyl cellulose as control. Determination of paralysis time (vermifuge) and death time (vermicidal) of the worms were noted. It was found that the ethanolic extracts of three plants exhibited significant anthelmintic activity at a concentration of 100mg/ml of MNE (highest activity) followed by SCE and HVE (least activity). The above traditional plants confirms the presence of ethanobotanical uses. The plants may be further explored for isolation of active constituents to bring a new active lead for suitable anthelmintic activity.

Novel thiazolopyrimidine derivatives (4a-l) were efficiently synthesized via the cyclo-condensation reactions of 2-(3-dimethylamino) acryloyl) phenyl 4-methylbenzene sulfonates with 2,3-dihydro-4-phenylthiazol-2-amines under microwave irradiation in ethanol catalyzed by iodine and the synthesized compounds were evaluated for their in vitro antimicrobial and anti-inflammatory activities. Among the newly synthesized compounds, 4d, 4h and 4l have exhibited potent antibacterial activity where as other derivatives 4b and 4j have showed moderate activity in comparison to standard drug amphcillin. The derivatives, 4d and 4l have displayed potent antifungal activity when their activity data was compared with standard drug norcadine. Some of the selected compounds were also screened for their anti-inflammatory activity and the results are compared with standard drug indomethacin. Among the derivatives, 4j possessed potent anti-inflammatory activity while 4b, 4f and 4k have exhibited moderate activity.

Quantum computing the recently invented computing power helps in carrying out calculations at really high pace. This will in other way boost the power of Artificial intelligence and its advantages to research activities altogether. As quantum computing computes at the power of qubits, so the artificial intelligence which is the intelligence of human mind would be enhanced. Hence this letter has been written in order to emphasize the development of super human power in terms of computers, which means the research would be done at super human intelligence. Keywords: Artificial Intelligence, Quantum computing, Super Human research development, Molecular Research

Medicinal Plants form the basis of traditional medicinal system. The medicinal plants usage is higher in developing countries with respect to the developed nations. In past the usage of medicinal plants use of medicinal plants and traditional medicines derived from medicinal plants has increased at great pace. The reported sales of medicinal plants or herbal medicines have crossed $ 60, 000 million dollars in year after 2000. Luffa accutangula is herbal plant, whose fruit is commonly used as vegetable as well as traditional medicines derived from medicinal plants were reported to be around 40 to 50 percent of population using it in Germany, around 43 percent usage in America, and around 48 percent in Australia and 49 percent in France. However in recent few decades (i.e. three decades) in Asian countries the sales have risen sharply. The plant is highly rich in medicinal values, and many pharmacological activities have been reported in the plant. Looking at the richness of Gourd (Luffa accutangula) the present review has been written in order to provide an up-to-date report on this imperative species of medicinal plant. Keywords: Medicinal plants, Herbal remedies, Pharmacology of medicinal plants, Luffa accutangula  

Gestational Diabetes Mellitus [GDM] is defined as the carbohydrate intolerance during pregnancy. In GDM glucose intolerance can be notified due to fetal development and other contributing factors, this may response to severe condition of hyperglycemia in pregnancy. Various maternal and prenatal adverse outcomes may resulted by GDM. The prevalence of GDM have a steep increase by  year to year by the influence of contributing factors such as advancing age,  life style modifications,  changed diet pattern etc. The overall prevalence of GDM noted as 1-14% among population, also the epidemiological studies states that the occurrence of GDM varies on the basis of ethnic and racial composition. The pathophysiology of gestational diabetes is assumed by various factors but exact cause of is unknown. Gestational diabetes is influenced by hormones produced by placenta, progesterone, estrogen, human placental lactogen [HPL], human chronic somatotropin [HCS] etc. Women with Polycystic Ovarian Syndrome [PCOS] and family history of Type 2 diabetes mellitus are at high risk of having GDM. GDM on pregnancy period causes some important complications such as high cesarean sections, preeclampsia, post partum type 2 diabetes mellitus, urinary tract infection in both neonate and the mother, cardiovascular disease,  hypertension and stroke in mother, also neonatal consequences such as congenital malformations, macrosomia, adiposity, hypoglycaemia, birth injuries and prenatal death. This overview describes all the complications of pregnant women and newborns due to GDM with the conclusion of treatment profile.

HPLC is the dominant separation technique in modern pharmaceutical and biomedical analysis because it results in highly efficient separations and in most cases provides high detection sensitivity. Most of the drugs in multi component dosage forms can be analyzed by HPLC method because of the several advantages like rapidity, specificity, accuracy, precision and ease of automation in this method. HPLC methods development and validation play important roles in new discovery, development, manufacture of pharmaceutical drugs and various other studies related to humans and animals. It is the most versatile, safest, dependable and fastest chromatographic technique for the quality control of drug components. This article was prepared with an aim to review different aspects of HPLC, such as principle, types, instrumentation, validation of HPLC and application. 

Zafirlukast, Cyclopentyl (3-(2-methoxy-4-((o-tolylsulfonyl) carbamoyl) benzyl)-1-methyl-1H-indol-5-yl) carbamate (I). A high-performance liquid chromatographic (HPLC) reversed-phase rapid resolution method has been developed and validated for estimation of zafirlukast in a pharmaceutical active pharmaceutical ingredient, which was chromatographed on reversed-phase Hypersil Gold C18 , 2.1 x 100 mm , 1.9 µ column using mixtures of acetonitrile/water and the eluents were monitored at different wavelengths. The method was validated statistically for its linearity, accuracy, robustness and precision. The method employed same chromatographic condition as above and validated in terms of linearity, accuracy, precision, limit of detection (LOD), limit of quantification (LOQ), and solution stability. Present work also describes the development and validation of RP- RRLC method for the determination of impurities of zafirlukast.

A highly efficient synthetic procedure were developed for the synthesis of bioactive pyrido [2,3-d] pyrimidines by  one-pot three component reaction of 6-amino 1,3-dimethyluracil, active methylene compounds and substituted aromatic aldehydes catalyzed using  urea catalyst  in aqueous media at room temperature. Mild reaction conditions, excellent yields, operational simplicity, no tedious separation procedures and clean reaction profiles are the key advantages of the present method. The bioactive synthesized derivatives showed no significant effect of electron donating or withdrawing moieties of the reacting aromatic aldehydes. This protocol produced the desired products in high yields (85-95 %) and short reaction times (45-75min) with reusability of reaction medium. Synthesized compounds were characterized by IR, 1HNMR & 13C NMR and mass spectral data.