Karnataka

To evaluate the physicochemical parameter. Anti-Helminthic  activity, Anti-Fungal activity and Anti-bacterial activity by various extracts (petroleum ether, chloroform, acetone, methanol) against various gram positive and gram negative bacteria (E.coli, Staphylococcus aureus and Bacillus subtilis) using a standard as Amoxicillin, Anti-Fungal activity (Candida Albicans, Aspergillus) using Ketoconazole and Anti-Helminthic  activity using a standard as Albendazole. The collected leaves of Rubus Ursinus were dried under shade for 10 days and then powdered into coarse particles in a mechanical grinder for further use, Extracted with petroleum ether, chloroform, acetone, methanol. Antihelmentic activity was evaluated on adult Pheritima Posthuma. Earthworms by subjecting to standard drug albendazole at a dose level of 10mg/ml and to the extracts of petroleum ether, chloroform, acetone, methanol at doses of 10mg/ml, 20mg/ml,25mg/ml 30mg/ml and 35mg/ml respectively. Anti-Fungal activity and Anti-bacterial activity was also performed against different bacteria by using disc diffusion method, the zones of inhibition of the extracts using standard as Amoxicillin and Ketoconazole  were determined. The powder leaves of Rubus Ursinus plant was subjected to extraction with four solvents petroleum ether, chloroform, acetone, methanol. High yield was obtained by methanol extracts of Rubus Ursinus plants. The qualitative test for methanol extraction was given positive tests for alkaloids, proteins & aminoacids,Tannins,Glycosides,FlavonoidsSaponins,Carbohydrates,Steroids& terpenoids and Phenolic compounds The anti-helmintic study and anti- fungal study of BlackBerry leaves was observed by using the extract of  methyl alcohol. The anti-bacterial study of various BlackBerry leaves extracts (petroleum ether, chloroform, acetone, methanol)  were found to be effective against various gram positive and gram negative bacteria. The leave part of plant of RUBUS URSINUS was observed for the Pharmacognostic investigation and Potent Anti-helmentic activity and significant Anti-Microbial activity. . The purified components may have even more potency with respect to inhibition of microbes. Key Words: RUBUS URSINUS, Amoxicillin, Ketoconazole, Albendazole

Ruta graveolens is a delicate plant until it is called as herb of grace. It is easily wither if it is happen to be touched with impure hands. In India it is considered as one of the sacred  plants .It has special fragrance .The leaves are bitter in taste .In Tamil it is called as Aruvatham patchai, and it is called as sada pillai as per siddha system of medicine , in Malayalam it is called as aruthu means no(Number), In Sanskrit it is called as santhapa,[KR Raman]. This plant nowadays have been used commonly as an ornamental plants in houses and institutes and other public areas, the medicinal knowledge  behind this plant  are still lacking with  the people whose planting this plant, the answer is just they say for gardening. Even though   lot  of study  was already made on this plant which is mentioned in an different literature  and books .The aim of this study is to bring out  some of the important traditional uses  and also to promote this plant for the  cognitive dysfunction which is recommended by personal  experience.

A tattoo is a form of body modification by inserting indelible ink into the dermis of the skin to change the pigment. Permanent makeup is a cosmetic technique which employs tattoos as a means of producing designs that resemble makeup. In the United States, the percentage of adults with minimum one tattoo has increased from 21% in 2012 to around 38% in 2016. The process of tattooing exposes the recipient to risks of infections with various pathogens, which are serious and difficult to treat. Other risks include allergic reactions, swelling and burning, granulomas, keloid formation and complications with MRI. Removal of tattoo is cumbersome. The pigments used in the inks are color additives, which are subject to premarket approval under the Federal Food, Drug, and Cosmetic Act. However, because of other competing public health priorities and a previous lack of evidence of safety problems specifically associated with these pigments, FDA traditionally has not exercised regulatory authority for color additives on the pigments used in tattoo inks. FDA only monitors problems from tattoos and permanent make-up and alerts the public when they become aware of a problem. Consumers should be aware of the risks involved in order to make an informed decision. FDA urges consumers and healthcare providers to report adverse reactions from tattoos, permanent makeup, and temporary tattoos, as well as problems with tattoo removal. But it’s high time that FDA takes a strong call on this matter and strictly regulates these practices to prevent further harm to public.

The studies were intended to investigate the possible antihyperlipidemic effect of tulsi and cinnamon oil in high cholesterol diet induced hyperlipidemic rats. Tulsi and cinnamon oil were evaluated for antihyperlipidemic activity using high cholesterol diet induced hyperlipidemia model in male Wistar albino rats(200-250g). A comparison was also made between the action of tulsi(0.5 mg/kg b.w) and cinnamon oil extracts(1.8mg/200g b.w) and antihyperlipidemic drug atorvastatin (0.18mg/200g). Parameters assessed were body weight, total cholesterol, triglyceride, HDL-C, LDL-C.  The results of the study are represented by mean ± SEM. Statistical significance of data was assessed by one way analysis of variance (ANOVA) followed by a comparison between different groups using “Tukey - Kramer” test. Oral administration of 0.5 mg/kg of tulsi oil with dist. water and Cinnamon oil of 1.8 mg/200g suspended in tween80 solution exhibited significant reduction (p ˂ 0.01) in serum biochemical parameters total cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL)  and increase in high density lipoprotein (HDL) levels in hyperlipidemic rats of HC diet model  compared to hyperlipidemic positive control. The results demonstrated that tulsi and cinnamon oil extracts possessed significant antihyperlipidemic activity.

A novel tridentate chelating ligand, (2Z,2Z)-3,3-dimethyl-2-(2-(2-oxoindolin-3-ylidene)hydrazono)butanoic acid and its Co(II), Ni(II), Cu(II) and Zn(II) complexes were synthesized and characterized by elemental analyses, spectral (vibrational, electronic, 1H NMR, 13C NMR and mass) and thermal studies. The interaction of ligand and complexes with calf-thymus DNA (CT-DNA) has been extensively studied using absorption, emission, viscosity and thermal denaturation studies with E. coli DNA. The DNA cleavage ability of ligand and metal complexes were tested using plasmid pBR322 DNA by gel electrophoresis method.

Plants have been an important source for developing drugs since time immemorial. Various medicinal herbs are indigenous to the Indian subcontinent and Asparagus is one such plant. Asparagus racemosus Willd., more commonly known as Shatavari, has been traditionally used in many systems of medicine such as Ayurveda, Unani and Siddha. It has been used for decades as a galactogogue, uterine tonic, adaptogen, and rejuvenator. Also it has been used to mitigate symptoms of peptic ulcer, as an immunostimulant, hepatoprotective, and aphrodisiac. In addition, several other health benefits of this wonder plant, such as antidepressant, antiamnesic, antianxiety, hypolipidemic, antidiabetic, and anticonvulsant effects have been discovered in the recent years. In this article, an effort has been made to comprehensively enumerate all the health benefits of A. racemosus, known so far.

The condensation of 2-hydrazino-4-phenyl thiazole and 3-formyl-2-hydroxyquinoline has led to the synthesis of a new Schiff base (L) and its series of mononuclear Co(II), Ni(II) and Cu(II) complexes have also been synthesized. The synthesized Schiff base and its metal complexes were characterized by elemental analyses, spectral techniques (FT-IR, 1H-NMR, 13C-NMR, GC-MS, ESI-MS, UV-Vis, etc;) and magnetic studies. Elemental analyses reveals the [M(L)2.(H2O)2] stoichiometry, where M= Co(II), Ni(II) and Cu(II); “L”= doubly deprotonated ligand. The synthesized metal complexes are completely soluble in DMF and DMSO. The molar conductivity values indicate that, the metal complexes are non-electrolytic in nature. The newly synthesized compounds are good anti-tuberculosis and cytotoxic agents. They have been screened for in-vitro antibacterial and antifungal activities by MIC method. The DNA cleavage activity is studied by agarose gel electrophoresis method using pBR322 Plasmid DNA.

The current investigation was delineated to find out the anticancer activity of three different formulations of Triphala and to find the best Triphala formulation for anticancer activity among the three. Aqueous extracts of Terminalia chebula, Termialia bellerica and  Phyllanthus emblica were obtained from Amruta herbals, Indore was dissolved in purified water to make Triphala 1:1:1, 1:2:3, 1:2:4 (F1, F2, F3 respectively) formulation. The number of 1x106 Ehrlich ascites carcinoma (EAC) cell was inoculated in mice. Group I served as untreated negative control while group II was considered as positive control. Group III cancerous animals received standard drug cyclophosphamide 25 mg/kg b.w., whereas group IV to VI cancerous animals were treated with F1 150, 300 and 600mg/kg b.w., group VIII to IX with F2 150, 300 and 600 mg/kg b.w and group X to XII with F3 150, 300 and 600mg/kg b.w., respectively. Different parameter such as change in body weight, determination of survival time, total ascites fluid volume, packed cell volume and haematological parameters were perceived. At the end of investigation, 6 animals from each group were immolated, blood samples were collected and WBC, RBC, Hb content was reckoned. The effect of all three formulations on reduction in body weight, tumor volume, packed cell volume, percentage increase in life span (%ILS) and haematological parameters were compared. The data revealed were suggested that all the three Triphala formulation possessed significant anticancer activity and Triphala 1:2:3 formulation at 600 mg/kg b. w., possessed maximum anticancer activity among the 9 groups compared. Key words: Triphala, Antitumor activity; Ehrlich ascites carcinoma.

Carica papaya, a member of the family Caricaceae, is commonly known for its food and nutritional value throughout the world. During last few decades considerable progress has been achieved regarding the biological activity and medicinal application of papaya and now it is considered as valuable neutraceutical fruit plant. The present study was designed to determine the antimutagenic and anticytotoxic activities of different fractions (Aqueous, Chloroform, Ethanol and Ethyl acetate extracts) of Carica papaya leaves. Antimutagenic activity was determined by the Allium cepa root chromosomal assay using Cyclophosphamide monohydrate as the mutagenic agent and anticytotoxic activity of the extracts was evaluated by determination of mitotic index. All the four fractions displayed significant antimutagenic and anticytotoxic activities against cyclophosphamide-induced chromosomal aberrations and alltogether, the results of our study lend pharmacological credence to the anti-cancerous and ethnomedical use of this plant in traditional system of medicine and these results could be used to develop antimutagenic compounds for cancer therapy.

Dalbergia sissoo (family: Fabaceae) is an Asian deciduous rosewood tree. It is the state tree of Punjab state (India) called as Shisham used for antipyretic, emesis, ulcers, leucoderma, stomach troubles and skin disease, memory enhancer etc. The aim of this study is to evaluate the antidepressant activity of ethanolic leaf extracts of Dalbergia sissoo in mice. The animals were divided into five groups of 6 each. Group I was considered as normal control, II as Standard control (Imipramine), III, IV and V was treated group (ethanolic leaf extracts of Dalbergia sissoo 300, 450 and 600 mg/kg respectively). The animals were acclimatized for behavioral tests like Tail suspension test and Forced swim Test. In behavioral model of depression Tail suspension test and Forced swim Test, ethanolic leaf extracts of Dalbergia sissoo decreased the immobility time significantly and increase in the first latency in dose dependent manner. The findings in the behavioral model of depression showed significant effect was due to the monoamine theory of depression.