Tulsi oil

The studies were intended to investigate the possible antihyperlipidemic effect of tulsi and cinnamon oil in high cholesterol diet induced hyperlipidemic rats. Tulsi and cinnamon oil were evaluated for antihyperlipidemic activity using high cholesterol diet induced hyperlipidemia model in male Wistar albino rats(200-250g). A comparison was also made between the action of tulsi(0.5 mg/kg b.w) and cinnamon oil extracts(1.8mg/200g b.w) and antihyperlipidemic drug atorvastatin (0.18mg/200g). Parameters assessed were body weight, total cholesterol, triglyceride, HDL-C, LDL-C.  The results of the study are represented by mean ± SEM. Statistical significance of data was assessed by one way analysis of variance (ANOVA) followed by a comparison between different groups using “Tukey - Kramer” test. Oral administration of 0.5 mg/kg of tulsi oil with dist. water and Cinnamon oil of 1.8 mg/200g suspended in tween80 solution exhibited significant reduction (p ˂ 0.01) in serum biochemical parameters total cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL)  and increase in high density lipoprotein (HDL) levels in hyperlipidemic rats of HC diet model  compared to hyperlipidemic positive control. The results demonstrated that tulsi and cinnamon oil extracts possessed significant antihyperlipidemic activity.

The purpose of present work was to prepare a nimesulide-loaded liquid suppository using menthol and to study the effects of various penetration enhancers such as neem oil, tulsi oil and ethanol on the cumulative percentage release of nimesulide. The physicochemical properties such as gelation temperature and gel strength of various formulations composed of nimesulide, menthol and poloxamer 188 were investigated. The in vitro study of nimesulide delivered by the liquid suppositories composed of poloxamer 188, menthol and various concentrations of penetration enhancers were performed. The in vitro studies were performed using Keshary-Chein diffusion cell and Small wonder (Lyzer apparatus). The cumulative percentage release of nimesulide of each formulation were calculated and compared with the other formulations. The liquid suppository formulations containing neem oil 2% and tulsi oil 2% showed excellent release rate as compared to other formulations.