Antidiabetic

Bauhinia variegata Linn widely used in folk medicine for varied purposes to treat different kinds of pathologies particularly diabetes, infections, pain and inflammation owing to the presence of numerous phytochemicals residing in the plant. The chemical constituents isolated so far from the plant are β-sitosterol, kaempferol-3-glucoside, tannins, carbohydrates, amides, reducing sugars, vitamin C, crude protein, fibers, calcium, phosphorus, quercetin, rutin, quercitrin, apigenin, apigenin- 7-O-glucoside, heptatriacontan-12, 13-diol and dotetracontan-15-en-9-ol. Different parts of Bauhinia variegata like leaves, bark and flowers have significant antioxidant activity. Bauhinia variegata can be considered as a model herbal drug for experimental studies including free radical induced disorders like cancer, diabetes, atherosclerosis etc.

The present study is undertaken to explore the effects of aqueous, alcoholic, chloroform and Petroleum ether extracts of Hibiscus rosa sinensis(HS), Aegle marmelos(AM), and Jatropha curcas(JC) on blood glucose level in both normal and alloxan induced diabetic rats.  In this single dose study, extracts are prepared by Maceration process with different solvents. Extracts of HS, AM, JC  was given once orally in different doses .The effect of extract was studied in normal rats, alloxan (150mg/kg, i.p.) induced diabetic rats and glucose fed normal rats by measuring fasting blood glucose level at different intervals. The extracts exhibited significant (p

The concerned study reveals antidiabetic effects of different polyherbal combinations of two medicinal plants used in traditional medicine. Aim of the present study was to evaluate antidiabetic action of polyherbal combination of two medicinal plants. Methanol: water (70:30) extracts of Carica papaya and Curry leaf were used for polyherbal combinations. All these combinations were studied for their acute toxicity and 200 mg/kg dose was selected. OGTT, antidiabetic activity and liver function tests were performed for all the combinations. Reduction in blood glucose level was determined in antidiabetic activity for 0 to 20 days and histopathology of the pancreas was performed after 20th day. Results revealed that all combinations were safe and dose was selected at 200 mg/kg. Polyherbal combinations II showed significant antidiabetic activity in OGTT and STZ-diabetic rats. Treatment with combination-II in diabetic animals produced beneficial improvement in lipid profile. Histopathological observations showed improvement in the rat treated with combination-II. It may be concluded that combination-II was most effective and safe in comparison to other combinations. Flavonoids, tannins and sterols present in this combination might be responsible for the effect.

Since immemorial time, utilization of medicinal plants has been in practice by the practitioner to treat variety of ailments without knowing the active bio-compound which lead to the reduction or elimination of symptoms of the disease. Recent advancement in technologies became a turning point in health care setting where many medicinal plants which are gifted from the nature were being employed in research to synthesized variety of phytochemical compounds which were responsible for the various pharmacological properties of the plants. Few compounds which were plant derivative have been patented for the commercial use to treat illness. In this review, medicinal plants related to few pharmacological properties like anticancer, antiviral, antidiabetics, antifungal were reviewed and documented. Also the phytochemical constituents were reviewed and documented. This review proved few related pharmacological properties of the plants where these plants were employed in the folk medicine. Advancement in technologies and also research fundings provide the suitable platform for the researchers to conduct extensive research on the medicinal plants.

In past there have been many medicinal plants, which have been used in traditional medicines for their antidiabetic properties without any scientific support and pharmacological evidence. The present study was undertaken to evaluate the antihyperglycemic activity of the crude extracts of leaves of Holarrhena antidysenterica. The pet ether, chloroform and ethanolic extracts have been subjected to estimate the anti-hyperglycemic activity in alloxan-induced diabetic rats. Blood glucose levels were measured using the commercially available glucometer. Glibenclamide was used as a reference drug at a dose of 0.6 mg/kg. The antioxidant activity of the test samples was studied in the liver tissue of diabetic rats by measuring catalase and lipid peroxidation levels. The results showed that ethanolic extract possessed a significant antihyperglycaemic and antioxidant activity equipotent with the reference drug (glibenclamide), when evaluated in diabetic rats.

  Two simple and sensitive visible spectrophotometric methods (A and B) have been developed for the quantitative estimation of Pioglitazone, in bulk drug and pharmaceutical dosage forms. Methods were based on the formation of Pale yellow coloured and green coloured chromo gens, which were measured 267 nm and 297 nm, respectively. The results obtained with the proposed methods are in good agreement with the labeled amounts when tablet dosage forms were analyzed.  For the first method, UV-spectrophotometry, standard solutions were measured at 267 nm. The first method was linear from 2.5-20 mg/mL. The second method was based on the formation of an ion association complex with Methyl orange (MO) and Bromocresol Green (BCG).The assay was found to be linear over the concentration range of 2.5-20 µg/mL. The wavelengths were selected dependent on the maximum obtained values. The formation of ion- pairs are formed between secondary amino group of PIO and MO, BCG reagents via the protonated nitrogen atom. The proposed methods were validated according to the ICH guidelines (1996) with respect to specificity, linearity, accuracy, precise and robustness. The results demonstrated that the procedure is accurate, precise, specific and reproducible (percent relative standard deviation