Diabetes.

The present work deals with the use of folklore medicine by tribal and non-tribal communities of Nalgonda district, Telangana state, India for controlling diabetes, a chronic disease. Here it is focused on the use of plant species as folklore medicine to cure diabetes by the ethnic groups. Preliminary phytochemical analysis was carried out with different extracts like distill water, petroleum ether, chloroform and methanol of folk medicine samples and their constituent plant parts from Nalgonda district. The folk medicine and the individual plant parts present in the sample showed the presence of similar kind of phytochemicals with various screening tests for the control of diabetes.

Bauhinia variegata Linn widely used in folk medicine for varied purposes to treat different kinds of pathologies particularly diabetes, infections, pain and inflammation owing to the presence of numerous phytochemicals residing in the plant. The chemical constituents isolated so far from the plant are β-sitosterol, kaempferol-3-glucoside, tannins, carbohydrates, amides, reducing sugars, vitamin C, crude protein, fibers, calcium, phosphorus, quercetin, rutin, quercitrin, apigenin, apigenin- 7-O-glucoside, heptatriacontan-12, 13-diol and dotetracontan-15-en-9-ol. Different parts of Bauhinia variegata like leaves, bark and flowers have significant antioxidant activity. Bauhinia variegata can be considered as a model herbal drug for experimental studies including free radical induced disorders like cancer, diabetes, atherosclerosis etc.

Drug Interactions have become very common now-a-days. In drug interactions there are mainly three types in that the most important interactions are drug-drug interactions. By keeping in mind about these interactions we have done research by taking Diabetes as the main disease and if same person is suffering any other disease like we have chosen Hypertension. Our main aim is to find out the Interactions between Glyburide and Amlodipine and another scenario is little different with another class of drug that is Enalapril and with Sulphonyl urea derivative drug that is Glyburide. We found that the Glyburide have shown the 49.9% of inhibition. The Amlodipine and Enalapril groups showed 28.9% and 33.7% inhibition rates against the Glyburide group. The combined groups Glyburide with Amlodipine and Glyburide with Enalapril have shown 39% and 43.3% inhibition rates. More results can be obtained if we have done Pharmacokinetic study.