OGTT

The concerned study reveals antidiabetic effects of different polyherbal combinations of two medicinal plants used in traditional medicine. Aim of the present study was to evaluate antidiabetic action of polyherbal combination of two medicinal plants. Methanol: water (70:30) extracts of Carica papaya and Curry leaf were used for polyherbal combinations. All these combinations were studied for their acute toxicity and 200 mg/kg dose was selected. OGTT, antidiabetic activity and liver function tests were performed for all the combinations. Reduction in blood glucose level was determined in antidiabetic activity for 0 to 20 days and histopathology of the pancreas was performed after 20th day. Results revealed that all combinations were safe and dose was selected at 200 mg/kg. Polyherbal combinations II showed significant antidiabetic activity in OGTT and STZ-diabetic rats. Treatment with combination-II in diabetic animals produced beneficial improvement in lipid profile. Histopathological observations showed improvement in the rat treated with combination-II. It may be concluded that combination-II was most effective and safe in comparison to other combinations. Flavonoids, tannins and sterols present in this combination might be responsible for the effect.

The present study was performed to validate floklore claims of leaves of Corchorus trilocularis using ethanol extract for its antihyperglyceamic activity in alloxan induced diabetic rats. Ethanolic extract of C. trilocularis (EtCT) and glyburide were administered orally in alloxan induced diabetic rats. In the acute study, the serum glucose level was estimated at 0, 2, 4, 6 and 24 h after drug administration. The subacute study involved repeated administration of the drugs for 28 days, a serum glucose level estimation at 7, 14, 21 and 28 days. In the OGTT, D-glucose (2.5 g/kg) was administered in diabetic rats half an hour after pre-treatment with EtCT and glyburide. Serum glucose levels were estimated 30 min prior to glucose administration and at 0, 30, 60 and 120 min after glucose loading. In EtCT (400 mg/kg), the onset was 4 h, the peak effect was 6 h but the effect waned at 24 h. In subacute study, repeated administration (once a day for 28 days) of the glyburide and EtCT caused a significant reduction in the serum glucose level as compared to the vehicle treated group. EtCT (400 mg/kg) treatment prevented a decrease in the body weight of the diabetic rats. In the OGTT, EtCT (400 mg/kg) increased the glucose threshold at 60 min after the administration of glucose. The EtCT (400 mg/kg) showed significant antihyperglyceamic activity than EtCT (100 and 200 mg/kg).It can be concluded that ethanolic extract of C. trilocularis has antihyperglyceaamic activity.