Kiran

The present study was aimed to evaluate the wound healing activity of extract of seeds of Swietenia macrophylla. It is well-known plant in Asian traditional medicines. On the basis of traditional use and literature references, this plant was selected for wound healing potential. The ethanolic extract of seeds of Swietenia macrophylla was examined for wound healing activity in the form of ointment in the excision wound model using Albino rats. The extract ointments showed efficient response in the excision wound model as comparable to the group treated with standard drug Betadine ointment and control group in terms of wound contracting ability, wound closure time and epitheliallization period. Histological analysis was also consistent with the proposal that Swietenia macrophylla seed extract exhibits significant wound healing. Swietenia macrophyllan was found to possess significant wound healing property. This was evident by decrease in wound closure (P

To develop and evaluate Push Pull Osmotic tablets of ketorolac Tromethamine (KT). Core tablets of KT were formulated by wet granulation method using polymers (HPMC K4M, K15M) , coated with semipermeable membrane (cellulose acetate), plasticizer (PEG 400) , pore former (D- sorbitol) and osmogen (sodium chloride). Compatibility studies were carried out using Differential Scanning Calorimetry(DSC), no incompatibility between the drug and polymers observed. The Physical properties of tablets were evaluated for thickness, hardness, friability, drug content, effect of osmotic agent, percentage of pore former, pH, agitational intensity, weight gain, osmotic pressure and in vitro drug release for 12 hours. Release studies best fitted to zero order pattern, indicating drug release was non-Fickian, independent of pH and agitational intensity. The system is simple, cost effective and alternative to conventional osmotic pump since sophisticated laser drilling technique is not required.

The novel series of 2-mercaptobenzimodazole derivative were synthesized by using secondary amine i.e. diethyl amine and aromatic aldehyde. In Mannish reaction instead of formaldehyde other aromatic aldehyde was used. This was main aim of present study. Same derivatives were synthesized by using Microwave technique & reaction time, practice yield were compared. The purity of synthesized compounds was checked by Melting point and TLC and their structure was established by various analytical techniques such as IR,1HNMR, Mass spectral studies. These Compounds were screened for their  Anticonvulsant activity.  Anticonvulsant activity was evaluated by PTZ induced model. Keyword- Mannich reaction, 2-Mercapto Benzimidazole, Aromatic aldehyde.

Plants have been used as medicines for thousands of years. They have always been used as a rich source of biologically active drugs. According to WHO (World Health Organization) report, about 80% of the population, mostly in developing countries still depends on traditional medicinal system for their primary health care. The present investigation is focused on the phytochemical investigation of abutilon indicum species for anticancer activity. The Abutilon L. genus of the Malvaceae family comprises about 150 annual or perennial herbs, shrubs or even small trees widely distributed in the tropical and subtropical countries. The aqueous extract of the A. indicum L. showed significant cytotoxic activity against both the selected cancer cell lines viz. human breast cancer cell line MCF 7 and human lung cancer cell line A 549.

Organic farming is a form of agriculture that relies on techniques such as crop rotation, green manure, compost, and biological pest control. Depending on which the definition of organic farming  is described for the  use of fertilizers and pesticides covering herbicides, insecticides and fungicides having natural origin for examplebone meal from animals or pyrethrin from flowers, but it excludes or strictly limits the use of various methods (including synthetic petrochemical fertilizers and pesticides; plant growth regulators such as hormones; antibiotic use in livestock; genetically modified organisms human sewage sludge; and nanomaterials. for reasons including sustainability, openness, independence, health, and safety. When we go on ancient Ayurvedic literatures on Vrikshayurveda it is found that during ancient period when synthesis of inorganic fertilizers, hormones antibiotics etc were not described for use on crop or other plants use of crop rotation, animal flesh, bones belonging to different animals and plant parts and Ayurvedic medicines like Triphala, Manjishtha, Ashwagandha, neem, tila along  with other ayurvedic formulations or single drugs from about 135 medicinal plants with holistic approach and the plant health were well maintained. Ancient Ayurvedic literatures also describe the creation of mango fruits on banana plants. Use of fish powder or extracts of plants to induce flowering and fruiting are used as tool under Vrikshayurveda. Fumigation from time to time for the control of several diseases is also a part of Vrikshayurveda for the maintenance of plant health which is now being popularized by Homa Therapy and Organic farming even for the maintaining human health. Seeking out all above aspects for creating linkage between organic farming and ancient Ayurvedic literature authors have conducted experiment on pea and gram crops by the use of Neem, Karanj, Behaya and Swet Kutaj just to compare effects of each drug on said crops. 

The purpose of this article brings out the fabrication and recent clinical research in osmotic drug delivery system. The technology of osmotic drug delivery system need to be modified for the conventionally control over their release and almost control the safe and effective concentration in the targeted sites. The certain phenomenon of molecule may have low bioavailability hence to be improve by the fabrication osmotic drug delivery system is most promising system for controlled drug delivery system. The pump and technique most is used to developed the research point of view. The number of marketed oral osmotically driven system (OCDDS) has doubled in the last 11 years. The osmotic pressure utilized for osmotic drug delivery system (OCDDS).

In pharmaceutical industry the major problem of dosage form development is low aqueous solubility. In present review the particle engineering concept and solubility, permeability approaches design and method used in improvement of particle size. The different methods are used in particle engineering like supercritical fluid technology, controlled precipitation, and mechanical technique, evaporation precipitation to aqueous solution, freezing technique, and sonication technology etc. discussed. The improvements of aqueous solubility need to be formulation development for dosage form very essential. The BCS class II drugs modified to soluble form for need of bioavailability of drugs. The solid dispersion method with a different carrier improves the solubility.

Nanotoxicology is an emerging new multidisciplinary field of science. This new technology deals with measures, manipulates, and manufactures at the atomic, molecular, and supramolecular levels, aimed at creating materials, devices, and systems with fundamentally new molecular organizations, properties, and functions associated with greater strength, stability, chemical and biological activity. They are used in rapidly increasing nanoproducts, nanodevices, electronics, diagnostics and drug delivery systems. They are present in a variety of consumer products such as foods, drugs, cosmetics, food colour additives, food containers, paints and surface coatings. Because of their extremely small size they are capable of entering the human body by inhalation, ingestion, skin penetration, intravenous injections and medical devices, and have the potential to interact with intracellular macromolecules. Because of their greater stability they are anticipated to remain in the body and in the environment for long periods of time. However, information on their potential adverse health effects is very limited at the present time. It is not known at what concentration or size they can exhibit toxicity. Therefore, there are obvious public safety concerns. This has led to the initiation of a new research discipline commonly known as Nanotoxicology. The current review article reveals the concept of Nanotoxicology from nanomedicine and non-medical nanoparticles.

The research involve formulation and evaluation of three different ophthalmic solutions of Ketorolac tromethamine with three different amino acid transporters. The prepared formulations were subjected to ex-vivo transcorneal permeation and cornea hydration studies through excised goat cornea and the results were compared with those of a prepared standard Ketorolac tromethamine ophthalmic solution. The trans corneal permeation studies were carried out by using an all glass Franz diffusion cell. The non-steroidal anti-inflammatory drug Ketorolac tromethamine ophthalmic solution is indicated for the temporary relief of ocular itching due to seasonal allergic conjunctivitis and also for the treatment of inflammation following cataract surgery. In the study, the three amino acid transporters used were Lysine, Phenylalanine and Valine which are responsible for protein synthesis and play a significant role in the process of maintaining structural and functional integrity of conjunctiva and retina. The results obtained from the permeation studies of conjugated physical mixtures of Ketorolac tromethamine with different amino acid transporters across the excised goat cornea were observed to exhibit enhanced permeation when compared with the permeation of Ketorolac tromethamine from the standard formulation.

Poisonous plants may be a threat to the health and safety of people and animals. It makes crucial to have knowledge about surrounding poisonous plants. Information gathered by generating database of poisonous materials from any particular region may be life saving. Chemical analysis of these plants is another important aspect especially for forensic experts solving crime cases involving poisonous plants. Therefore this paper has also conducted Thin Layer Chromatographic separation of poisonous plants. A wide diversity of plants could be seen in and around Rohtak city of Haryana but literature survey didn’t reveal any significant information about the poisonous plants from this area. Therefore, the present study has inspected occurrence of some poisonous plants throughout Rohtak city and their chromatographic analysis. Importantly the results have been of great utility. Morphological examination identified ten poisonous plants vis. Thevetia peruviana, Nerium odoratum, Calotropis procera, Ricinus communis, Datura fastusa, Argemone mexicana, Ipomea marginate, Crinium asiaticum, Plumeria obtuse and Abrus precatorius from different localities of the selected area.  A new single solvent system chromatographically separating all these poisonous plant extracts has also been developed.