Fabrication

The purpose of this article brings out the fabrication and recent clinical research in osmotic drug delivery system. The technology of osmotic drug delivery system need to be modified for the conventionally control over their release and almost control the safe and effective concentration in the targeted sites. The certain phenomenon of molecule may have low bioavailability hence to be improve by the fabrication osmotic drug delivery system is most promising system for controlled drug delivery system. The pump and technique most is used to developed the research point of view. The number of marketed oral osmotically driven system (OCDDS) has doubled in the last 11 years. The osmotic pressure utilized for osmotic drug delivery system (OCDDS).

Unique properties of Nanofibers have attracted for the designing of controlled drug delivery systems due to high surface area to volume ratio, porosity so only we can applied in advance application such as Biodegradable and controlled drug delivery systems. The benefits of the fibrous carriers are site specific delivery of drugs to the body. Nanofibers are an exciting new class of material produced using an innovative manufacturing process technology. These fibers are produced from a variety of polymers in geometrical shapes ranging from Nonwoven web, yarn, and bulk structures. The Synthetic polymer Nanofibers are made from Nylon, Acrylic, Polycarbonate, Polysulfones, and Fluro polymers among other polymers. The biological polymer nanofibers are made from materials such as Polycaprolactum, Chitosan, Polylactic acid, and Copolymer of Polylactic/glycolic acid among other biopolymers. At present, there are three techniques available for the synthesis of Nanofibers: Electro spinning, self-assembly, and phase separation, out of these Electro spinning is the most widely used technique. Mostly , the bioactive molecules like anti-cancer drugs, enzymes. Cytokines, and polysaccharides can be entrapped within the interior or physically immobilized on the surfaces of nanofiber for controlled drug delivery. The advanced approach for creating Nanofibers made of proteins developed, greatly improve drug delivery methods for the treatment of cancers, heart, and Alzheimer’s diseases, as well as aid in the regeneration of human tissue, bone and cartilage. This review paper reports on fabrication of nanofibers and its characteristics and high tech application in drug delivery, tissue engineering and filter medium.