Wound healing

The present study was aimed to evaluate the wound healing activity of extract of seeds of Swietenia macrophylla. It is well-known plant in Asian traditional medicines. On the basis of traditional use and literature references, this plant was selected for wound healing potential. The ethanolic extract of seeds of Swietenia macrophylla was examined for wound healing activity in the form of ointment in the excision wound model using Albino rats. The extract ointments showed efficient response in the excision wound model as comparable to the group treated with standard drug Betadine ointment and control group in terms of wound contracting ability, wound closure time and epitheliallization period. Histological analysis was also consistent with the proposal that Swietenia macrophylla seed extract exhibits significant wound healing. Swietenia macrophyllan was found to possess significant wound healing property. This was evident by decrease in wound closure (P

The present work aims at evaluating the wound healing potential of a traditional plant Piper betle (PB) of both leaves and stem. The ethanolic extract of both Piper betle leaves and stem were investigated to evaluate the rate of wound healing enclosure and the histology of healed wounds in rats. Four groups of adult female albino wisttar rats were experimentally wounded at the dorsal region of the rats. Group 1 animals were left with untreated and set as negative control. Group 2 animals were treated with 10% Povidone Iodine, and set as positive control. Group 3 and 4 treated with ointment formulation containing 10% Piper betle leaves and 10% Piper betle stem leaves extract respectively. All the four groups are treated with for 21 days. Wound healing was assessed by rate of wound closure estimation and histology studies on the 21st day of post wounding. 10% Piper betle stem enhanced the wound healing process by increasing rate of wound closure compared to negative control group. Histological observation also showed better organized tissue and more collagen fibers in 10% Piper betle stem treated group. These results strongly document the significant effect of 10% Piper betle stem extract to accelerates the rate of wound healing and closure in the experimentally induced wound rats.

The methanolic extract of Punica granatum (PUG), Glycyrrhiza glabra (GLA) and their combination (PUG-GLA) were evaluated for their wound healing activity using excision wound model in rats. Rats treated with PUG-GLA showed higher rate of wound contraction, significant decrease in epithelization period and significant increase in hydroxyproline content of granulation tissue when compared with the controls. The histological examination of treated wounds showed that the original tissue regeneration was much greater in PUG-GLA, with increase in the restoration of collagen fibers, fibroblasts, blood vessel formation and hair follicle regeneration.