ethanolic extract

The present study was aimed to evaluate the wound healing activity of extract of seeds of Swietenia macrophylla. It is well-known plant in Asian traditional medicines. On the basis of traditional use and literature references, this plant was selected for wound healing potential. The ethanolic extract of seeds of Swietenia macrophylla was examined for wound healing activity in the form of ointment in the excision wound model using Albino rats. The extract ointments showed efficient response in the excision wound model as comparable to the group treated with standard drug Betadine ointment and control group in terms of wound contracting ability, wound closure time and epitheliallization period. Histological analysis was also consistent with the proposal that Swietenia macrophylla seed extract exhibits significant wound healing. Swietenia macrophyllan was found to possess significant wound healing property. This was evident by decrease in wound closure (P

To study the effects of ethanolic extracts of Vernonia amygdalina(VA) and Ocimum gratissimum (OG)on the testes of diabetic rats, thirty-two male rats were used. Control consisted of eight (8) rats which served as non- diabetic control, receiving sodium citrate daily. The remaining rats were injected intraperitoneally with streptozotocin(65mg/kg) to induce diabetes. The rats confirmed diabetic were randomly divided into three experimental groups (1, 2 and 3) made up of eight rats each. Group 1 received 6IU/kg of insulin. Group 2 was given 100mg/kg body weight of Vernonia amygdalina and 200mg/kg body weight of Ocimum gratissimum combined daily. Group 3 served as the diabetic control and was given distilled water. The entire investigation lasted for 6 weeks. Results revealed typical testicular architecture in the normal control. Diabetic control exhibited alteration of germinal epithelium, distortion of seminiferous tubules as well as vacuolation of seminiferous tubules. The effects of the extracts on diabetic rats’ testes showed improvements compared to the diabetic control group. It is therefore safe to speculate that the extracts of these plants used especially when combined exert some significant improvement in combating the adverse effects of diabetes on the testes of male rats.