rats.

The anti ulcer activity of the hydro alcoholic extract of the leaves of Acridocarpus excelsus was studied in vivo using WISTAR rats. This study investigated the extract’s effect on gastric ulcer induced by indomethacin orally administered at the dose of 30mg/kg, acid secretion by pylorus ligation and mucus secretion. The results obtained showed that ulceration provoked by the indomethacin on the gastric mucosa surface was reduced from 13.12 ± 0.96 mm2 found inthe control group to 8.15± 0.12 mm2, 2.87 ± 0.41 mm2  and  1.25 ± 0.05 mm2 respectively in the rats treated with the extract at doses 150 mg/kg, 300 mg/kg and 600mg/kg (p

To study the effects of ethanolic extracts of Vernonia amygdalina(VA) and Ocimum gratissimum (OG)on the testes of diabetic rats, thirty-two male rats were used. Control consisted of eight (8) rats which served as non- diabetic control, receiving sodium citrate daily. The remaining rats were injected intraperitoneally with streptozotocin(65mg/kg) to induce diabetes. The rats confirmed diabetic were randomly divided into three experimental groups (1, 2 and 3) made up of eight rats each. Group 1 received 6IU/kg of insulin. Group 2 was given 100mg/kg body weight of Vernonia amygdalina and 200mg/kg body weight of Ocimum gratissimum combined daily. Group 3 served as the diabetic control and was given distilled water. The entire investigation lasted for 6 weeks. Results revealed typical testicular architecture in the normal control. Diabetic control exhibited alteration of germinal epithelium, distortion of seminiferous tubules as well as vacuolation of seminiferous tubules. The effects of the extracts on diabetic rats’ testes showed improvements compared to the diabetic control group. It is therefore safe to speculate that the extracts of these plants used especially when combined exert some significant improvement in combating the adverse effects of diabetes on the testes of male rats.