Heterocycles

In the modern world, a number of heterocycles have emerged and are showing important roles in a variety of human-beneficial pharmaceutical compounds. Pyrazoles are nitrogen-containing heterocyclic compounds with five members. They have garnered a lot of attention because they belong to a significant class of chemicals for therapeutic development and Quinolines, A typical example of bicyclic heterocyclic compounds. Meanwhile, derivatives of pyrazole and quinoline have been synthesized as target structures and have shown a wide range of biological actions, including antitubercular, anticancer, antifungal, anti-inflammatory, antibacterial, and anti-tuberculosis properties. The findings of published studies on the synthesis and biological activity of quinoline and pyrazole derivatives are compiled in this review. The Scopus database was consulted to gather and evaluate the published research papers on the biological activities and synthesis of pyrazole and quinoline derivatives that were published between January 2019 and December 2023.

Thiazolidinones have been explored in both academia and pharmaceutical industry for their wide spectrum of biological applications which include activity against streptomyces species, anti-convulsant, hypoglycemic, antihypertensive agents and therefore, they are useful molecules for drug research and organic chemistry. Thiazolidinone derivatives containing thiazole ring system are also found to possess pharmacological activities such as anticancer, antimalarial, tuberculostatic, anticonvulsant, anti-HIV activity and CNS stimulants. Extensive research in the synthesis and biological evaluation of thiazolidinone substituted heterocycles is well documented and hence, attracted the interest of organic chemist. Therefore, the objective of this review to highlight the biological properties of thiazolidinone derivatives bearing thiazole ring system. The introductory paragraph highlights the significance of the thiazolidinone moiety and is followed by an overview of thiazole heterocycle. In the next section pharmacological properties of thiazolidinone linked thiazole derivatives has been described Key words: 4-Thiazolidinone, Thiazole, Heterocycles, Biological Activity 

Chemistry of heterocyclic organic compounds is as logical as that of aliphatic/aromatic compounds and of great interests both from the theoretical as well as practical synthetic view to design novel compounds that becomes one of the most important areas of research today. Electron-flux of six member/annulated N heterocycles plays vital roles to exhibit diverse potent biological activities from pharmaceuticals to industrial materials. The Pyrimidine and fused pyrimidine annulated rings in the chemistry of biological systems has attracted much attention due to availability in the substructures of therapeutic imperative natural products. As a result of their prominent and remarkable pharmacological activity, pyrimidine derivative’s intensive research has been made especially focused on its anticancer activity. The present review gives brief information about anticancer activity of assorted six member/annulated pyrimidine derivatives.

Cancer is an important area of interest in the life sciences because it has been a major killer disease throughout human history. Heterocyclic molecules are well known to play a critical role in health care and pharmaceutical drug design. Currently a number of heterocyclic compounds are available commercially as anticancer drugs and great efforts have been put to the identification of novel anticancer targets for novel anticancer drug discovery. Key words: Heterocycles, Cancer