4-Thiazolidinone

Thiazolidinones have been explored in both academia and pharmaceutical industry for their wide spectrum of biological applications which include activity against streptomyces species, anti-convulsant, hypoglycemic, antihypertensive agents and therefore, they are useful molecules for drug research and organic chemistry. Thiazolidinone derivatives containing thiazole ring system are also found to possess pharmacological activities such as anticancer, antimalarial, tuberculostatic, anticonvulsant, anti-HIV activity and CNS stimulants. Extensive research in the synthesis and biological evaluation of thiazolidinone substituted heterocycles is well documented and hence, attracted the interest of organic chemist. Therefore, the objective of this review to highlight the biological properties of thiazolidinone derivatives bearing thiazole ring system. The introductory paragraph highlights the significance of the thiazolidinone moiety and is followed by an overview of thiazole heterocycle. In the next section pharmacological properties of thiazolidinone linked thiazole derivatives has been described Key words: 4-Thiazolidinone, Thiazole, Heterocycles, Biological Activity 

A series of novel schiff bases containing N-benzyl piperidine moiety (1a-d) were synthesized by the reaction of N-benzylpiperidine-4-carbaldehyde with suitable aromatic amines. And synthesized schiff bases were converted to a series of novel 4-thiazolidinones (2a-d) by the reaction of Schiff base with mercaptoacetic acid. The chemical structures of the synthesized compounds were confirmed by using spectroscopic and chemical analysis techniques. All the above compounds were screened for their antimicrobial activity against some selected pathogenic microorganism. Good level of antimicrobial activity has been displayed by both categories of compounds against tested pathogenic microorganism. Thiazolidinone derivatives (2a-d) showed higher activity than schiff base derivatives (1a-d).