anticancer

In the modern world, a number of heterocycles have emerged and are showing important roles in a variety of human-beneficial pharmaceutical compounds. Pyrazoles are nitrogen-containing heterocyclic compounds with five members. They have garnered a lot of attention because they belong to a significant class of chemicals for therapeutic development and Quinolines, A typical example of bicyclic heterocyclic compounds. Meanwhile, derivatives of pyrazole and quinoline have been synthesized as target structures and have shown a wide range of biological actions, including antitubercular, anticancer, antifungal, anti-inflammatory, antibacterial, and anti-tuberculosis properties. The findings of published studies on the synthesis and biological activity of quinoline and pyrazole derivatives are compiled in this review. The Scopus database was consulted to gather and evaluate the published research papers on the biological activities and synthesis of pyrazole and quinoline derivatives that were published between January 2019 and December 2023.

A series of 2-(Bis(2-chloroethyl)amino)-N-(4-((3-oxobenzofuran-2(3H)-ylidene)methyl) phenyl)acetamide derivatives were synthesized by fusing aurones with nitrogen mustards. Aurones being synthesized by treating 4-nitrobenzaldehydes with various derivatives of 1-(2-hydroxyphenyl)ethenone. The characterization of the synthesized compounds was done by FTIR, 1H NMR and LCMS spectral studies. The titled compounds were tested for their possible anticancer activities by in vitro methods by SRB Assay.  These compounds were found to exhibit a moderate anticancer activity.

Cubosomes are bicontinuous cubic liquid crystalline phases formed by the self-assembly of polar lipids, monolein, in water. They offer unique physicochemical properties than the other common colloidal delivery systems such as liposomes and nanoparticles. The article reviews about definition of cubosomes, advantages and disadvantages, composition and different production and characterization techniques. Moreover, there is an emphasis on the importance of cubosomes for the effective delivery of anticancer drugs.

Azetidin-2-ones (β-lactams) have been a mainstay as therapeutics for the treatment of a wide range of bacterial infections. The interest in β-lactams stems from their highly unusual structure-activity profiles towards a genera of pathogenic bacteria. Tremendous efforts have been made in the literature towards the development of novel β-lactam compounds for a study of their biological evaluation. The present review begins with a brief introduction of β-lactam antibiotics. This is preceded by the progress made towards the biological evaluation of a variety of racemic as well as optically active cis- or trans-3-acetoxyazetidin-2-ones. Their application in medicinal field as antifungal, antibacterial, antitumor, anticancer, IMR32 cytotoxic agents and carbonic anhydrase inhibitors is discussed.