Cubosomes

Cubosomes are square and adjusted particles with inner cubic cross section. Cubosomes are thermodynamically steady and comprise of honeycombed (enormous) structures isolating two inward watery channels and a huge interfacial region. Cubosomes are nanoparticles which are self gathered fluid translucent particles of specific surfactants with appropriate proportion of water with microstructure that gives extraordinary properties of commonsense interest. Bicontinuous cubic fluid glasslike stage is optically clear and extremely thick material has the special design at nanometer scale. The word bicontinuous alludes to the division of the two ceaseless however non-meeting fluid areas by lipid bilayer that is wound into space filling structure. Hydrating a surfactant or polar lipid that structures cubic stage and afterward scattering a strong like stage into more modest particles generally shapes a Cubosomes. Self-gathered Cubosomes as dynamic medication conveyance frameworks are getting increasingly more consideration and interest after the primary revelation and assignment. They show different inward cubic design and creation with various medication stacking modalities. It has high inward surface region and cubic translucent designs, somewhat basic planning strategy, biodegradability of lipids, the capacity of typifying hydrophobic, hydrophilic and amphiphilic substances, focusing on and controlled arrival of bioactive specialists. Cubosomes are having wide scope of uses in different fields and they can be described by different assessment boundaries. Along these lines, Cubosomes are acquiring consideration in drug field.

The discovery of the cubosomes is the unique story & spans the fields of the food science, biological membranes, differential geometry & digestive processes. The cubosomes are the square & rounded particles with the internal cubic lattices visible. The cubosomes are self-assembled nanostructured particles formed by the aqueous lipid & surfactant systems. The cubosomes are the thermodynamically stable, they have the structure like “honeycombed” with the bicontinuous domains of the water & lipid in which the surfactant assembles into the bilayers & twisted into the 3 dimension, periodic & the minimal surface forming the structure which are tightly packed. They exhibit the different internal cubic structure & composition with different drug-loading modalities. In drug nano formulations the cubosome have great potential for the melanoma therapy owing to their potential advantages which includes high drug payloads due to the high internal surface area & cubic crystalline structures relatively biodegradability of lipids, the simple preparation method, targeting & controlled release of the bioactive agents, the ability of encapsulating the hydrophilic, hydrophobic & amphiphilic substances, The cubosome dispersions are biocompatible & bioadhesive. Due to their properties the cubosome are versatile systems administrable by different routes such as parenterally, orally& percutaneously. Hydrating the surfactant or the polar lipid that forms the cubic phase & then dispersing the solid like phase into the smaller particles usually forms the cubosomes. To encapsulate guest molecules such novel particles are utilized which are either amphiphilic, lipophilic or hydrophilic due to its structure compartmentalization.

Cubosomes are bicontinuous cubic liquid crystalline phases formed by the self-assembly of polar lipids, monolein, in water. They offer unique physicochemical properties than the other common colloidal delivery systems such as liposomes and nanoparticles. The article reviews about definition of cubosomes, advantages and disadvantages, composition and different production and characterization techniques. Moreover, there is an emphasis on the importance of cubosomes for the effective delivery of anticancer drugs.