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An efficient synthesis of N-glucosylated 1, 2, 4-dithiazolidines from 1-arylidene-4-arylthiosemicarbazides and N-tetra-O-acetyl-β-D-glucopyranosylimino chloromethane sulphenyl chloride has been worked out. 1-Arylidene-4-arylthiosemicarbazides were synthesized by reacting different aryl/hetero aryl aldehydes/ketones with 4-arylthiosemicarbazides. The identities of new glucosylated heterocycles have been established on the basis of usual chemical transformation, IR, NMR and mass spectral studies. The final compounds were screened for biological activity against different bacterial strains.

A new series transition metal complexes of Cu(II), Co(II), Ni(II) and Zn(II)  complexes have been synthesized from 2-(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)phenol (AMPT). The nature of bonding and the geometry of the complexes have been deduced from elemental analyses, magnetic susceptibility, infrared, electronic, 1H NMR, 13C NMR, and EPR spectral studies. The redox behavior of copper complexes was studied by cyclic voltammetry.  The second harmonic generation (SHG) efficiency was measured by Kurtz and Perry method. The ligand and their metal complexes were screened by Well diffusion method. The interaction of complexes with CT- DNA was investigated by viscosity measurement. Results suggest that all the complexes bind to DNA via an intercalative mode. The DNA cleavage ability of all the complexes was examined on calf thymus (CT-DNA) plasmids using gel electrophoresis experiment in presence of H2O2. From the results it is concluded that all the complexes cleave DNA.

A series of 3-amino-5-sugarimino-1, 2, 4-thiadiazolines have been synthesized by oxidative cyclization of sugar-3-amidinothiocarbamides by using bromine. These amidino thiocarbamides were prepared by interaction of guanidine and sugar isothiocynates. Guanidine itself plays an important role as antifungal, anticancer activities when it links with glycosides its acivity increased. These newly synthesized compounds have pharmaceutical uses. The identities of these newly synthesized compounds have been established on the basis of usual chemical transformation and IR, 1H NMR, and Mass spectral studies. The synthesized compounds were screened for their in vitro antimicrobial activities using human pathogens.

A series of novel benzimidazoles derivatives were synthesized in convenient, easy and cheap way. These benzimidazoles are characterized by bearing amino substituents (morpholine and N-methylpiperazine) at positions 5, in addition to pyrimidine, pyridine, furyl, thienyl and pyryl with amide linkage at positions 2. The methodology of such synthetic routes was represented in synthesis of novel structures that the microbes have never been presented with before; that would hopefully prevent the process in which microbes resist antimicrobial drugs. The structures of all new compounds were identified by 1H-NMR, 13C-NMR, M.S and FT-IR spectroscopic techniques and elemental analysis. All the compounds synthesized in this work were examined for their in vitro antimicrobial activities against Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli), and the fungi (C.albicans and A.niger). Compared to Ciprofloxacin and Fluconazole as the reference substances, some of the synthesized compounds showed high antibacterial and antifungal activities against studied strains with inhibition zones between (12-27) mm. 

2 (H/substituted)-4-aryl-5H,6H, 7-arylimino-1,2,3,5,6-thiatetraazepines (6) have been obtained by basification of 2-(H/substituted)-4-aryl-5H,6H-7-arylmino-1,2,3,5,6-thiatetraazepine monohydrochloride (5).  The latter were synthesized by the interaction of N-aryl-S-chloro isothiocarbamoyl chloride (4) and 1-(H / substituted)-3-aryl-dihydroformazan (3), which were prepared initially by the condensation of aryl acid hydrazide (1) and hydrazine hydrate or substituted hydrazine (2). Compound (6) on benzoylation with benzoyl chloride and excess 10 % sodium hydroxide solution afforded benzoyl derivatives (7) and on boiling with aqueous ethanolic sodium hydroxide solution isomerizes into corresponding 1, 2, 3, 5, 6-pentaazepines (8).  The structures of all the synthesized compounds were established on the basis of elemental analysis, equivalent weight determination, spectral analysis like IR, 1H-NMR and Mass.  These newly synthesized compounds (6) were screened for their antifungal and antibacterial activity.