antimicrobial activity.

A new series of azetidinone derivatives have been synthesized due to the growing resistance of bacteria towards the â-lactam antibiotics. In our present study Oxadiazole is synthesized from semicarbazide is on condensation with substituted aldehyde to form Schiff base. The schiff bases are cyclized with chloroacetylchloride in triethylamine to yield the corresponding 2-azetidinones. Structures of synthesized compounds are confirmed by physical & spectral analysis. The compounds have screened for antimicrobial activity.

Co(II), Fe (III) and Cu (II) metal complexes of Schiff base derived from ethylenediamine, succinic acid and formaldehyde. The newly synthesized Schiff base complexes were characterized by elemental analysis, Melting point, conductivity, IR and UV-VIS spectral methods. The complexes have been tested for their antimicrobial activity against bacteria and fungi. The anti- microbial activity was determined in Mueller Hinton media (M H Media).

A series of 3-amino-5-sugarimino-1, 2, 4-thiadiazolines have been synthesized by oxidative cyclization of sugar-3-amidinothiocarbamides by using bromine. These amidino thiocarbamides were prepared by interaction of guanidine and sugar isothiocynates. Guanidine itself plays an important role as antifungal, anticancer activities when it links with glycosides its acivity increased. These newly synthesized compounds have pharmaceutical uses. The identities of these newly synthesized compounds have been established on the basis of usual chemical transformation and IR, 1H NMR, and Mass spectral studies. The synthesized compounds were screened for their in vitro antimicrobial activities using human pathogens.

A series of 6-tetra-O-acetyl-β-D-glucopyranosylimino 2 dimethylamino-4 aryl/alkyl imino-1,4,5,6 tetrahydro-1,3,5 triazines have been synthesized by the interaction of tetra-O-acetyl α-D glucopyranosyl bromide and various 1,3,5 triazines. The latter were synthesized by following the interaction of metformin hydrochloride and N-aryl/alkyl imino isocyanodichloride in chloroform medium. The identities of these new N-glucosylated triazines have been established on the basis of elemental analysis, I.R., NMR and mass spectral studies. The newly synthesized compounds were screened for their antimicrobial and antifungal activities. Some of them showed moderate to less antimicrobial activity.

Benz-fused compounds have been employed in the synthesis of various compounds which show very potential pharmacological activities. Carbohydrate is the key element in variety of biological phenomena and its N-linked sugar derivatives also exhibit wide range of medicinal activities. Keeping in this view, when one biological active molecule is linked to another, the resultant molecule generally has increased potency.Hence for the first time, in present work, we have interacted two pharmocophores, hepta-O-benzoyl-β-D-lactosyl isothiocyanate  and substituted 2-hydrazino-1,3-benzothiazoles in acetone medium to yield hepta-O-benzoyl-β-D-lactosyl-3-(2)-hydrazino-1,3-benzothiazolyl thiocarbamides. The identities of these newly synthesised hepta-O-benzoyl-β-D-lactosyl-3-(2)-hydrazino-1,3-benzothiazolyl thiocarbamides have been established on the basis of usual chemical transformations and IR , 1H NMR and Mass spectral studies. The antibacterial and antifungal activities of also reported. Some of these derivatives exhibit significant antimicrobial activity. Key words: Lactosyl isothiocyanate, hydrazino benzothiazoles, lactosyl hydrazino benzothiazolyl thiocarbamides, antimicrobial activity.

Fifteen new Fluorine substituted Schiff bases were prepared by condensation of different substituted benzaldehyde with 4-fluoroaniline. The structures of these Schiff bases have been confirmed by IR, 1H NMR, mass and elemental analysis. All the new compounds synthesized have been evaluated for their action against bacteria and fungi. Key words: Schiff bases, 4-fluoroaniline, substituted benzaldehyde, antimicrobial activity.