N-glucosylated 1

An efficient synthesis of N-glucosylated 1, 2, 4-dithiazolidines from 1-arylidene-4-arylthiosemicarbazides and N-tetra-O-acetyl-β-D-glucopyranosylimino chloromethane sulphenyl chloride has been worked out. 1-Arylidene-4-arylthiosemicarbazides were synthesized by reacting different aryl/hetero aryl aldehydes/ketones with 4-arylthiosemicarbazides. The identities of new glucosylated heterocycles have been established on the basis of usual chemical transformation, IR, NMR and mass spectral studies. The final compounds were screened for biological activity against different bacterial strains.

A series of 6-tetra-O-acetyl-β-D-glucopyranosylimino 2 dimethylamino-4 aryl/alkyl imino-1,4,5,6 tetrahydro-1,3,5 triazines have been synthesized by the interaction of tetra-O-acetyl α-D glucopyranosyl bromide and various 1,3,5 triazines. The latter were synthesized by following the interaction of metformin hydrochloride and N-aryl/alkyl imino isocyanodichloride in chloroform medium. The identities of these new N-glucosylated triazines have been established on the basis of elemental analysis, I.R., NMR and mass spectral studies. The newly synthesized compounds were screened for their antimicrobial and antifungal activities. Some of them showed moderate to less antimicrobial activity.