Lactosyl isothiocyanate

Several 1-aryl-5-hepta-O-benzoyl-β-D-lactosyl-2-S-benzoyl-2, 4-isodithiobiurets have been synthesized by the interaction of hepta-O-benzoyl-β-D-lactosyl isothiocyanate with several 1-aryl-S-benzyl isothiocarbamides. These compounds were screened for their antibacterial and antifungal activities against–Escherichia coli, Proteus vulgaris, Staphylococcus aureus, Salmonella typhimurium, Klebsiella pneumonie, Psudomonasaeruginosa, Aspergillus niger and Candida albicance.  The newly synthesized compounds have been characterized by analytical and IR, 1H NMR and Mass spectral studies. These compounds show appreciable activity towards these microorganisms.

Benz-fused compounds have been employed in the synthesis of various compounds which show very potential pharmacological activities. Carbohydrate is the key element in variety of biological phenomena and its N-linked sugar derivatives also exhibit wide range of medicinal activities. Keeping in this view, when one biological active molecule is linked to another, the resultant molecule generally has increased potency.Hence for the first time, in present work, we have interacted two pharmocophores, hepta-O-benzoyl-β-D-lactosyl isothiocyanate  and substituted 2-hydrazino-1,3-benzothiazoles in acetone medium to yield hepta-O-benzoyl-β-D-lactosyl-3-(2)-hydrazino-1,3-benzothiazolyl thiocarbamides. The identities of these newly synthesised hepta-O-benzoyl-β-D-lactosyl-3-(2)-hydrazino-1,3-benzothiazolyl thiocarbamides have been established on the basis of usual chemical transformations and IR , 1H NMR and Mass spectral studies. The antibacterial and antifungal activities of also reported. Some of these derivatives exhibit significant antimicrobial activity. Key words: Lactosyl isothiocyanate, hydrazino benzothiazoles, lactosyl hydrazino benzothiazolyl thiocarbamides, antimicrobial activity.