Santosh

Dispersible drug delivery methods are widely utilized nowadays to increase patient compliance and bioavailability. Dispersible tablets have drawn a lot of interest over the last three decades as a better option to traditional tablets and capsules because of their enhanced solubility, stability, and patient compliance. Dispersible tablets may be a better option, particularly for medications that are sensitive to gastrointestinal fluids, to cover up the bitter taste of the medication, and for patients who fall into the paediatric, geriatric, bedridden, postoperative, or other patient categories and may have trouble swallowing traditional tablets and capsules. These tablets instantly break down in the water to create the suspension. The key component of a dispersible tablet is the super disintegrants. When a dispersible tablet comes into touch with water, it becomes moist and swells significantly, which causes it to dissolve rapidly. The improved compliance among patients is facilitated by the new medicine administration mechanism. Among these are pills that dissolve quickly. Benefits of readily dispersed tablets include precise dosage, ease of production and transportation, strong chemical and mechanical stability, and a perfect substitute for elderly and paediatric patients. Because of its many benefits, such as simplicity of ingestion, pain avoidance, adaptability, and, most importantly, compliance from patients, the oral route of taking medication continues to be the most optimal method. The most popular solid dose forms are tablets and capsules.

Herbal cream have various studies have been done to assess the antiseptic potential of Blumea Lacera and Turmeric. Blumea Lacera have Activity of antiseptic and antioxidant. Antiseptic a substance that Prevents or arrests the growth or action of micro-organisms either by inhibiting their activity or by destroying them. For all above problem ayurvedic has a fast acting solution in a form of cream which has herbal medicines with antiseptic potential. Another traditional use minor burns and cuts. This cream is not only useful in antiseptic but also to normalize skin colour by erasing scars naturally. The prepared formulations were evaluated based on number criteria including, physical parameters, PH test, wash ability test, phase separation test.

The triazoles possess wide spectrum of biological activities like including antibacterial, antifungal, antiviral, anti-inflammatory, anticonvulsant, antidepressant, antihypertensive, analgesic, and hypoglycemic properties. The present reviews attempted to gather the basic developments in synthesis and biological activities of triazole derivatives. The novel chemical moiety used in medicinal active substance either (R) or (L) hence Dextro or Levo rotatory form. The broad spectrum of activity is due nitrogen hence nitrogen containing loan pair of electron transfer to another substance and formation of covalent bond.

Nasal drug delivery system offers way of drug delivery of both topical and systemic therapies. The high permeability, high vasculature and low enzymatic environment of nasal cavity are well suitable for systemic delivery of drug molecules via nose. The despite of all the advantages of nasal drug delivery, the bioavailability of nasally administered products, especially for protein and peptide molecules, is affected by many barriers such as physiological barriers, physicochemical barriers, and formulation barriers. This review will focus on the various bioavailability barriers in nasal drug delivery and the strategies to improve the bioavailability of nasal dosage form

In the pharmaceutical industry the course is designed to give you the skills that have taken many experienced The New Drug Application (NDA) is an application submitted to U.S.FDA for permission to market a new drug product in the United States. The New Drug Application (NDA) is an application submitted to U.S.FDA for permission to market a new drug product in the United States. The components of any NDA are a function of the nature of the subject drug and the information available to the applicant at the time of submission. The form to use for either NDA or ANDA is Form FDA-356h, Application to Market a New Drug for Human Use or as an Antibiotic Drug for Human Use. The international regulatory authorities under consideration are WHO, USFDA, MHRA, and Australian TGA. The standard institutions give the economical background for development and transferring technologies, ISI, ISO, BISS and ASTM. To legally gather this data on safety and effectiveness in the U.S., the maker must first obtain an Investigational New Drug (IND) designation from FDA.

A novel Quality by Design methodology was used to develop and validate a rapid, accurate, precise, simple, efficient and reproducible isocratic Reversed Phase-High Performance Liquid Chromatographic (RP-HPLC) method for the estimation of Luliconazole in bulk and pharmaceutical dosage form. Luliconazole was separated using Kromasil C18 column (250mm×4.6 mm, 5µm particle size), Shimadzu LC2030 HPLC system having UV detector and the mobile phase contained a mixture of 0.01M Ammonium acetate buffer and Acetonitrile (35:65). The flow rate was set to 1.2 ml/min with the responses measured at 294nm. The retention time of Luliconazole was found to be 3.092 min. Central composite design employed for design of experiment and optimization. Desirability value was found to be 0.723 and overall model was found to significant. Linearity was established for Luliconazole in the range of 20-120 µg/ml with correlation coefficient (r2=0.9995). Limit of detection (LOD) and limit of quantitation (LOQ) were evaluated and found to be 1.1700 and 3.5455 respectively. The accuracy values were found to be in the range of 98 –102% and every parameter found with in limit. Validation parameters were evaluated for the method according to the International Conference on Harmonization (ICH) Q2 R1 guidelines. This method can be used for the estimation and analysis of Luliconazole drug in active pharmaceutical ingredients and pharmaceuticals.

This experiment, first developed for a NSF Novel Process Workshop, is a highly visual experiment in chemical engineering processes and experimentation. In addition, it the coating process is environmentally benign because it has essentially no volatile emissions. The object of the experiment is to place a protective coating on a pellets, tablets, and metal object. The metal object is coated by first heating in a hot air stream and then dipping the object into a fluidized bed of thermoplastic powder. This experiment can be used throughout the curriculum.  For recruitment at the precollege and freshman level the fluid motion of the gas and particles can be observed through the clear plastic walls of the fluidized bed.  Using brightly colored particles gives the fluid bed the look of an executive desk amusement.  Prospective students and freshman can also feel the water like quality of the bed using a rod or ruler.  Freshmen use the fluidized bed as an example of the engineering measurements of flow rate, temperature, pressure and coating thickness.  They design an experiment to determine the desired coating thickness by varying the dipping time and temperature of the object.

To improve the solubility enhancement of solid dispersion of Lopinavir by spray-drying by adding the Soluplus as polymer that is compatible with Lopinavir, was evaluated and the process used for preparation of Spray dried solid dispersion was validated and the 1:3 ratio used for preparation of solid dispersion. Dissolution tests were carried out on several spray dried solid dispersion of Lopinavir and physical mixture. The solid dispersion characterized by DSC, XRD, % Entrapment Efficiency, solubility study, drug content determination, practical yield, dissolution studies.

In the pharmaceutical industry the course is designed to give you the skills that have taken many experienced auditors decades to develop. It follows the auditing guidance of ISO-19011 and is a virtual audit of a manufacturing facility that makes a range of dosage forms. This allows you to plan and prepare audits of the supplier and your own supplier audit system. Throughout the course, there is personal practice with exercises and teamwork’s in planning, preparation and performance that address WHO. The extensive of course notes and excellent lectures given by knowledgeable and professional tutors in pharmaceutical industry, The WHO was very easy to approach with any problems in during the course. The purpose of regulatory authorities to assess application for authorization to market products for human use and either grant authorizations to market each product or reject such applications and inspect the manufacturers and wholesalers of medicines for human use and either grant manufacturing and wholesale licenses or refuse such licenses. The international regulatory authorities under consideration are in this article WHO, USFDA, MHRA, and Australian TGA. The standard institutions give the economical background for development and transferring technologies, ISI, ISO, BISS and ASTM. 

The long circulatory liposome means shows action towards target organ longer period of time. Liposome are the concentric bilayer in which aqueous volume entirely envelope by the lipid bilayer used to transfer enzymes, protein and drugs to targets cancer cell or tissue. These are chemical moieties in which action towards target organ. It was first discovered by 1965 and soon was proposed drug delivery system. There are numerous application like anti fungal, anti cancer, anti inflammatory and anesthetic drugs. The magic bullet concept of Poul-Ehrlich et al; through very late, offers a logical solution to the age old problem unrelated and unwanted effect of therapeutic agent and optimizing the drug therapy in its true sense. The controlled, sustained and controlled drug delivery can be considered as the magic bullet concept. The long circulatory liposome gives the stealth effect called as killer bomber to cancer cell and arrest the Mitosis of M-phase and G-phase.