Santosh

An attempt has been made in the present research to formulate periodontal inserts of  Satranidazole (STZ) to increase residence time and prolong drug release. The periodontal inserts were prepared using chitosan, a natural biodegradable polymer. Chitosan inserts containing Satranidazole (10%, 20% and 30% to the weight of polymer) were prepared by solution casting method using 1% v/v acetic acid in water. Further inserts containing 30% Satranidazole were cross-linked by exposing to the vapours of 2% v/v glutaraldehyde in water for two different time period of 2 and 4 hours to retard the release of drug. FTIR and DSC studies revealed that there was no interaction between drug and polymers. The inserts were then evaluated for their physicochemical parameters like uniformity of thickness, weight, folding endurance, % moisture loss, tensile strength; drug content and in vitro drug release studies.  In vitro drug release data indicated that the films showed an initial burst release followed by sustained release of the drug. The drug-loaded films that were not cross linked had released the drug up to 10 days and the films which were cross linked for different duration showed a progressive fall in the release of the drug and extended up to 18 days.

  ODTS are solid unit dosage form which dissolve or disintegrate rapidly in mouth without water. So, acceptability of this dosage form mainly depends on its taste i.e. mouth feel. So it becomes necessary to develop such an ODT for that must be acceptable in taste to patient many techniques are available to mask the taste of drugs. These techniques not only serve as to mask the taste of drug but also to enhance the bioavailability of drug. Taste masking technology involves the development of a system that prevents the active substance interacting with the taste buds, thereby eliminating or reducing the bitter taste. This review describes the commonly used techniques that are adopted for masking the taste of bitter drugs and dosage form palatable. The common methods include addition of sweeteners, coating of drugs adjusting the pH values, granulation, freeze drying, forming complex with ion exchange resins etc. Key words: orodispersible tablets (ODTs), taste masking.