Satranidazole

The colon drug delivery system has gained recent importance in delivery of the drug to the colon. These system facilitate the delivery of the drug to the colon and mainly releases the drug in the colonic environment and thereby reduces various side effects of conventional dosage forms like lower dose is required and hence lowering the side effects caused by higher doses. In the present study natural polysaccharide approach is employed and sesbania gum powder was used as a carrier for delivery of the drug to the colon . Satranidazole was selected as a drug of choice because it is most potent nitroimidazole derivative and clinically useful against common protozoa, it is twice as effective as other nitroimidazoles against amoebiasis. Colon targeted tablet of satranidazole can maintain minimum inhibitory concentration for desired duration in fewer doses with fewer side effects. The aim of the present research work is to develop core tablets of satranidazole and compression coated with different ratios of sesbania gum powder. All the formulations were then subjected for evaluation and were tested for hardness, drug content uniformity an in vitro drug release studies. The compression coated formulation CCS 2 released less than 5% of satranidazole drug in the physiological environment of stomach and intestine, when the dissolution studies was further continued in simulated colonic fluids the compression coated tablets with 150mg of sesbania gum powder released another 70% of satranidazole in the colon after degradation by colonic bacteria at the end of 12 hrs.

An attempt has been made in the present research to formulate periodontal inserts of  Satranidazole (STZ) to increase residence time and prolong drug release. The periodontal inserts were prepared using chitosan, a natural biodegradable polymer. Chitosan inserts containing Satranidazole (10%, 20% and 30% to the weight of polymer) were prepared by solution casting method using 1% v/v acetic acid in water. Further inserts containing 30% Satranidazole were cross-linked by exposing to the vapours of 2% v/v glutaraldehyde in water for two different time period of 2 and 4 hours to retard the release of drug. FTIR and DSC studies revealed that there was no interaction between drug and polymers. The inserts were then evaluated for their physicochemical parameters like uniformity of thickness, weight, folding endurance, % moisture loss, tensile strength; drug content and in vitro drug release studies.  In vitro drug release data indicated that the films showed an initial burst release followed by sustained release of the drug. The drug-loaded films that were not cross linked had released the drug up to 10 days and the films which were cross linked for different duration showed a progressive fall in the release of the drug and extended up to 18 days.