HPMC.

Montelukast Sodium are formulated as lozenges to provide slow release medicament for the management of chronic asthma and allergic rhinitis. The benefits of prepared lozenges showed increase in bioavailability, reduction in gastric irritation, bypassing of first metabolism and increase in onset of action.The molded lozenges can provide an attractive alternative formulation in allergic conditions.  The lozenges are prepared using sucrose, liquid glucose, Hydroxy propyl methyl cellulose K4M (HPMC K4M). Sodium Saccharine along with flavors are used to mask the bitter taste of drug. All the formulations prepared are subjected to various physicochemical parameters like weight variation, hardness, thickness, friability, content uniformity, and moisture content etc. The prepared formulations have a hardness of 8-11 kg/cm2, non-gritty and pleasant mouth feel. Some selected formulations are also tested for drug excipient interactions subjecting to IR Spectral analysis, In vitro release rate studies showed that the drug release for lozenges was maximum in formulation F6 (99.3±0.52%) at 30 minutes.

The present study includes the Formulation and Evaluation of Mucoadhesive Buccal Patch of Timolol Maleate for this study work timolol maleate selected as model drug and using either ionic polymers (SCMC) or non-ionic polymers (carbopol, HPMC).The fabricated patches were prepared by solvent casting method.  The mean thicknesses of the buccal patch formulations were 0.34 – 0.43 mm. Moisture uptake of transdermal patches were found to be 2.94-4.13.which prevents the patches from microbial growth and bulkiness. As amount of PVP increased in every polymer blend, tensile strength and elongation at break were increased. Addition of PVP predominantly decreased the swelling characteristics of the buccal patches, except for SCMC. The drug content of the prepared bioadhesive buccal patches were found in the range of 91.4 - 98.54 %.Bioadhesive strength of buccal patches in following order SCMC >Carbopol>HPMC. The release of Timolol maleate from HPMC patches was slower than SCMC and CP 934.As PVP concentration increased, dissolution rate increases among all polymers. For determination of λmax the solution of the timolol maleate was subjected to ultraviolet scanning in the rage 200 to 400 nm. The λmax was found to be at 294 nm .The pH of formulations was found to be 6.8 - 7.5 which is within the limit of semisolid specifications. The folding endurance of BP formulations was found to be 296 – 325.The results indicated that all formulations were flexible and soft. Bioadhesive buccal patches containing SCMC, HPMC and Carbopol showed a zero order drug release.

Fast dissolving oral films (FDOFs) are the most advanced form of oral solid dosage form due to more flexibility and comfort. Fast dissolving film is a dosage form which when placed in the oral cavity, quickly gets hydrated, sticks onto the site of application and then disintegrates to release the drug. Fast dissolving oral films of isosorbide mononitrate were prepared by solvent casting method. Optimization was carried out to study the effect of independent variables (different polymer and plasticizer concentration) such as HPMC E5 and HPMC E50 as polymer and PEG 400 as a plasticizer on the dependent variables like T90% (sec), in-vitro disintegration time (sec) & % moisture absorption (%). Design expert software (version 8.0.1.6) was used to optimize the formulation. Prepared films were subjected to different evaluation parameters such as surface pH, weight uniformity, thickness of strip, % moisture absorption, % moisture loss, swelling index, drug content, in-vitro disintegration time, in-vitro drug release, stability studies and mechanical properties like folding endurance, tensile strength.

Recently, fast dissolving films are gaining interest as an alternative of fast dissolving tablets. The present study aimed at preparing fast dissolving oral films of Naratriptan hydrochloride as a model drug which is used for the migraine treatment. Fast dissolving dosage forms have acquired great importance in pharmaceutical industry because of their unique properties like dissolve upon contact with a wet surface, such as the tongue, within a few seconds, meaning the consumer can take the product without need for additional liquid. This convenience provides both a marketing advantage and increased patient compliance. In the present investigation various trials were carried out using two grades of HPMC (E3 and E6), Propylene glycol, PEG-400 and other polymers by solvent casting method.  The prepared films were evaluated for film thickness, folding endurance, surface pH, morphological properties, %drug content and content uniformity, tensile strength, percent elongation, in vitro disintegration time and in vitro dissolution studies. The optimized formulation S11 prepared using HPMC E6 showed minimum disintegration time (10 sec), highest dissolution rate i.e. 98.23% of drug within 6 min and satisfactory physicochemical properties. Results of DSC and FTIR data of optimized formulation (S11) revealed that there was no incompatibility observed between the drug and excipients used in the formulation. These findings suggest that the fast dissolving oral film containing Naratriptan hydrochloride is considered to be potentially useful for the treatment of migraine where quick onset of action is desirable when compared with reference standard Naratrax conventional tablet.

Gastroretentive dosage forms have potential for use as controlled-release drug delivery systems. The use of floating dosage forms is one method to achieve prolonged gastric residence times, providing opportunity for both local and systemic drug action. The present work was aimed to formulate floating tablets of Itopride hydrochloride using an effervescent approach for gastroretentive drug delivery system. The present investigation concerns the development of floating tablets of Itopride hydrochloride, a novel prokinetic drug, which after oral administration are designed to prolong the gastric residence time and thereby increase drug bioavailability, and drug release rate. This would help in promoting gastrointestinal transit and speed up gastric motility, and thereby it will relieve the symptoms associated with it. Floating tablets were fabricated; using direct compression method; containing Itopride hydrochloride, polymers HPMC K100M, HPMC K15M and HPMC K4M, along with gas generating agent sodium bicarbonate. The floating tablet formulations were evaluated for physical characterization, assay, swelling index, in‐vitro drug release, hardness, friability and weight variation.