Buccal Patch

The present study includes the Formulation and Evaluation of Mucoadhesive Buccal Patch of Timolol Maleate for this study work timolol maleate selected as model drug and using either ionic polymers (SCMC) or non-ionic polymers (carbopol, HPMC).The fabricated patches were prepared by solvent casting method.  The mean thicknesses of the buccal patch formulations were 0.34 – 0.43 mm. Moisture uptake of transdermal patches were found to be 2.94-4.13.which prevents the patches from microbial growth and bulkiness. As amount of PVP increased in every polymer blend, tensile strength and elongation at break were increased. Addition of PVP predominantly decreased the swelling characteristics of the buccal patches, except for SCMC. The drug content of the prepared bioadhesive buccal patches were found in the range of 91.4 - 98.54 %.Bioadhesive strength of buccal patches in following order SCMC >Carbopol>HPMC. The release of Timolol maleate from HPMC patches was slower than SCMC and CP 934.As PVP concentration increased, dissolution rate increases among all polymers. For determination of λmax the solution of the timolol maleate was subjected to ultraviolet scanning in the rage 200 to 400 nm. The λmax was found to be at 294 nm .The pH of formulations was found to be 6.8 - 7.5 which is within the limit of semisolid specifications. The folding endurance of BP formulations was found to be 296 – 325.The results indicated that all formulations were flexible and soft. Bioadhesive buccal patches containing SCMC, HPMC and Carbopol showed a zero order drug release.

The study aim was concerned with formulation and in vitro evaluation of mucoadhesive buccal patch of carvedilol, which is extensively metabolized by liver. During last few years mucoadhesive dosage forms have promoted an area of drug delivery system that renders the treatment more effective and safe, not only for topical disorders but also for systemic problems. Therefore the present investigation is concerned with the development of the bucco-mucoadhesive patches, which were designed to prolong the buccal residence time, to increase penetration through buccal mucosa and thus increase the bioavailability. Various formulations were developed by using release rate controlling patches forming polymers like HPMC (K15, K4), HPC-L, Sodium alginate, PVP K30& Carbopol 934P in  alone & various combinations by solvent casting technique using plasticizer glycerol. For unidirectional release, backing layer prepared using ethyl cellulose 2.5%w/v dissolve in isopropyl alcohol and acetone. Glycerol used as a plasticizer was casted on the patches. The patches were evaluated for their thickness uniformity, folding endurance, weight uniformity, content uniformity, swelling behaviour, tensile strength, and surface pH, In vitro release studies, in vitro residence time, in vitro diffusion study. Patches exhibited drug release (diffusion) in the range of 75.69% to 96.53%. Kinetic models i.e. Higuchi, Korsemeyer-peppas, zero order were applied on data of diffusion release to explain release. The optimized formulation (F1) shows the zero order release.