PEG

Fast dissolving oral films (FDOFs) are the most advanced form of oral solid dosage form due to more flexibility and comfort. Fast dissolving film is a dosage form which when placed in the oral cavity, quickly gets hydrated, sticks onto the site of application and then disintegrates to release the drug. Fast dissolving oral films of isosorbide mononitrate were prepared by solvent casting method. Optimization was carried out to study the effect of independent variables (different polymer and plasticizer concentration) such as HPMC E5 and HPMC E50 as polymer and PEG 400 as a plasticizer on the dependent variables like T90% (sec), in-vitro disintegration time (sec) & % moisture absorption (%). Design expert software (version 8.0.1.6) was used to optimize the formulation. Prepared films were subjected to different evaluation parameters such as surface pH, weight uniformity, thickness of strip, % moisture absorption, % moisture loss, swelling index, drug content, in-vitro disintegration time, in-vitro drug release, stability studies and mechanical properties like folding endurance, tensile strength.

Domperidone is a water insoluble drug exhibiting poor dissolution pattern. Domperidone is an antiemetic and shows gastroprokinetic properties. It is a weak base and shows poor solubility in alkaline pH. Several methods are being employed to enhance the solubility of domperidone irrespective of its pH dependent solubility. The present protocol aim to design Polyethylene glycol (PEG) based solid dispersions of Domperidone to enhance its solubility. PEG 8000 based solid dispersions containing the drug in different mass ratio i.e. 1:1, 1:3, 1:5 and 1:7 were prepared using fusion method. The prepared solid dispersions were characterized for their drug content, phase solubility studies, Fourier-transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), x-ray diffraction, and in-vitro dissolution studies. All the formulations showed marked improvement in the solubility and dissolution rate of drug which may be due to decrease in crystallinity of drug and additives. It was concluded that prepared solid dispersion of the Domperidone with PEG can improve the solubility and dissolution rate of the drug.