Domperidone

The purpose of this research was to develop mouth dissolve tablets ofdomperidone andpantoprazole, were prepared by direct compression technique. Pantoprazole inhabits gastric acid formation and thereby it is very efficient for the treatment of gastric and duodenum ulcers. Domperidone, an antiemetic drug, has been used as an add-on treatment in adults and children. The tablets were prepared using microcrystalline cellulose as diluent and  aspartames as sweetening agent along with three different levels of disintegrant. The superdisintegrant used in this study were CCS and SSG. The tablets were evaluated for weight variation, hardness, friability, wetting time, water absorption ratio, disintegration time (DT) and dissolution study. formulation prepared with 30% of CCS showed Disintegration time of 20seconds in vitro. Also the hardness, friability, dissolution rate of prepared tablets (batch F6) were found to be acceptable according to standard limits.

  A simple and rapid method has been developed for the quantification of Domperidone (DMP) and Ranitidine (RAN) through FT-IR in combined dosage form. The method involves the measurement of peaks of amine (-NH) at 1620 cm-1 (RAN) and carbonyl group (C=O) at 1717 cm-1 (DMP). The method was validated for pharmaceuticals in tablet form and found to be precise with high recovery levels (>99%). Key words: FT-IR, Ranitidine, Domperidone, combined dosage form.

Domperidone is a water insoluble drug exhibiting poor dissolution pattern. Domperidone is an antiemetic and shows gastroprokinetic properties. It is a weak base and shows poor solubility in alkaline pH. Several methods are being employed to enhance the solubility of domperidone irrespective of its pH dependent solubility. The present protocol aim to design Polyethylene glycol (PEG) based solid dispersions of Domperidone to enhance its solubility. PEG 8000 based solid dispersions containing the drug in different mass ratio i.e. 1:1, 1:3, 1:5 and 1:7 were prepared using fusion method. The prepared solid dispersions were characterized for their drug content, phase solubility studies, Fourier-transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), x-ray diffraction, and in-vitro dissolution studies. All the formulations showed marked improvement in the solubility and dissolution rate of drug which may be due to decrease in crystallinity of drug and additives. It was concluded that prepared solid dispersion of the Domperidone with PEG can improve the solubility and dissolution rate of the drug.