FT-IR

Drugs are used in pharmaceutical formulation to serve the mankind and help them to maintain their Quality of Life. As per literature survey we found that there are a fair number of paper that explains the formulation of dosage form by certain drugs, but none of them with explaining the aspect of isolation and retrieving of the active drug from the dosage form. In the current study Paracetamol is taken as the active drug which is used to formulate the best batch of tablet and then the drug is retrieved back from the best found formulation by the help of specific solvent. This solvent was determined by trial of several combinations and the best selected results are mentioned. 96.24 % of the active agents were isolated by the help of selected solvent. The drug compatibility study was carried out by Fourier Transform Infrared spectroscopy (FT-IR) and the structure determination of the isolated active agent was carried out by the Nuclear Magnetic Resonance (NMR) results. The assay of isolated active agent was carried out by UV spectroscopy. All these analytical data helped to elucidate the structure of isolated active agent and was found similar to that of Paracetamol.

The biodiesel is quite similar to conventional diesel fuel in its physical characteristics and can be used alone or mixed in any ratio with petroleum based diesel fuel in most existing modern four-stroke combustion ignition diesel engines with very few technical adjustments or no modification. Biodiesel as a neat can be used as a direct substitute for petro diesel and is technically called B100.The reaction is catalyzed by NaOH making this process economically viable for the industrial scale production of biodiesel. Biodiesel is an excellent product as it is environmentally friendly. Chromatogram GC-MS analysis showed 12 peaks were detected as methyl esters of fatty acids in Biodiesel coconut oil but there is only one a prominent peak that has great intensity.

  A simple and rapid method has been developed for the quantification of Domperidone (DMP) and Ranitidine (RAN) through FT-IR in combined dosage form. The method involves the measurement of peaks of amine (-NH) at 1620 cm-1 (RAN) and carbonyl group (C=O) at 1717 cm-1 (DMP). The method was validated for pharmaceuticals in tablet form and found to be precise with high recovery levels (>99%). Key words: FT-IR, Ranitidine, Domperidone, combined dosage form.