paracetamol

Drugs are used in pharmaceutical formulation to serve the mankind and help them to maintain their Quality of Life. As per literature survey we found that there are a fair number of paper that explains the formulation of dosage form by certain drugs, but none of them with explaining the aspect of isolation and retrieving of the active drug from the dosage form. In the current study Paracetamol is taken as the active drug which is used to formulate the best batch of tablet and then the drug is retrieved back from the best found formulation by the help of specific solvent. This solvent was determined by trial of several combinations and the best selected results are mentioned. 96.24 % of the active agents were isolated by the help of selected solvent. The drug compatibility study was carried out by Fourier Transform Infrared spectroscopy (FT-IR) and the structure determination of the isolated active agent was carried out by the Nuclear Magnetic Resonance (NMR) results. The assay of isolated active agent was carried out by UV spectroscopy. All these analytical data helped to elucidate the structure of isolated active agent and was found similar to that of Paracetamol.

Gum from the peels of unripe plantain, Musa acuminata was extracted, after crushing, with distilled water and bleached with sodium hypochlorite solution. Five different granule batches of paracetamol were prepared with different concentrations of the powdered gum at concentrations of 2, 4, 6, 8, and 10 % respectively, as mucilage. The disintegrant and lubricant were maize starch and magnesium stearate at 5 and 1 % total tablet weights, respectively. The wet granulation method was used with the incorporation of the disintegrant intragranularly. Similar granulations were made with a commercial binder - sodium carboxymethylcellulose (SCMC) for comparison. The flow properties of the granules were evaluated and the granules were compressed into tablets. The physicochemical properties of the tablets were evaluated. The plantain gum was fairly white. The granules produced with plantain gum showed similar flow properties with those produced with SCMC. The tablets formulated with plantain gum were more friable that the tablets formulated with SCMC, though, the values became close with increase in adhesive concentration. The tablets formulated with plantain peel gum disintegrated and released the drug faster than those formulated with SCMC. For example, the T30% in 0.1 N HCl was 3 mins for granulations with 6% plantain gum, and 10mins for those formulated with 6% of SCMC. The results show that the gum from fresh peels of Musa acuminata could be a good alternative binder to the commercially sourced SCMC in pharmaceutical formulations.

A novel, precise and selective high performance liquid chromatographic method was developed for the estimation of paliperidone using paracetamol as the internal standard. Separation was achieved on a LiChrospher® RP-18 HPLC column (5 μ particle size and 25 cm × 4.6 mm internal diameter) using 10 mM ammonium acetate: methanol in the ratio of 10:90 (v/v) as the mobile phase, at flow rate of 0.7 ml/min and the eluate was monitored at 277 nm. The method was validated in compliance with ICH guidelines. The correlation coefficient of the calibration graph was 0.99946±0.00037 over the concentration range 1 to 5 µg mL-1. The limit of detection and limit of quantification were 0.569 µg mL-1 and 1 µg mL-1, respectively. Overall percentage recovery of paliperidone ranged between 98.92±0.595 to 100.30±0.693. Relative standard deviations for intra- and inter-day precision studies were