binder

Hibiscus rosasinensis Linn are used in medicines in emollients and also it is used to treat burning sensations and skin disease. Mucilage of Hibiscus rosasinensis contains L‐rhamnose, D‐galactose, D‐galactouronic acid, and D‐glucuronic acid. The present article is trying to present an investigation is to extract the mucilage from the petals of flower of Hibiscus rosasinensis and use it in a paracetamol tablets as a binder. As the mucilage having granulating and binding properties so it is used in tablets, using paracetamol as a model drug. The Ph of mucilage was found to be 6.5 and all the physicochemical properties i.e. solubility and swelling index was studied. In this investigation wet granulation technique is used for the formation of granules using the above described mucilage which having the concentration of 2%, 5% and 7% w/v to use as a binder.’

Gum from the peels of unripe plantain, Musa acuminata was extracted, after crushing, with distilled water and bleached with sodium hypochlorite solution. Five different granule batches of paracetamol were prepared with different concentrations of the powdered gum at concentrations of 2, 4, 6, 8, and 10 % respectively, as mucilage. The disintegrant and lubricant were maize starch and magnesium stearate at 5 and 1 % total tablet weights, respectively. The wet granulation method was used with the incorporation of the disintegrant intragranularly. Similar granulations were made with a commercial binder - sodium carboxymethylcellulose (SCMC) for comparison. The flow properties of the granules were evaluated and the granules were compressed into tablets. The physicochemical properties of the tablets were evaluated. The plantain gum was fairly white. The granules produced with plantain gum showed similar flow properties with those produced with SCMC. The tablets formulated with plantain gum were more friable that the tablets formulated with SCMC, though, the values became close with increase in adhesive concentration. The tablets formulated with plantain peel gum disintegrated and released the drug faster than those formulated with SCMC. For example, the T30% in 0.1 N HCl was 3 mins for granulations with 6% plantain gum, and 10mins for those formulated with 6% of SCMC. The results show that the gum from fresh peels of Musa acuminata could be a good alternative binder to the commercially sourced SCMC in pharmaceutical formulations.

The glidant and binding properties of starches extracted from three local potato tubers have been evaluated and compared with corn starch BP. The glidant properties studied include angle of repose, flow rate and flow factor while the binding properties were assessed by crushing strength and friability. The result indicated that potato starches employed as glidant were not as efficient as talc or corn starch but produced tablets with higher crushing strength and lower friability values. The results indicate that potato starches can be employed as an alternative binder to corn starch BP in the formulation of paracetamol tablets.