V.Rama

Transdermal patches have a high systemic impact and may increase absorption by bypassing hepatic first-pass metabolism. A transdermal therapeutic system allows drugs to be continuously administered into the systemic bloodstream at a predetermined rate through unbroken skin over an extended period of time. When piroxicam (PXM) is taken orally, it can cause headaches, exhaustion, dry mouth, nose, and throat, nausea, vomiting, and sleepiness. It is also insoluble in water, so its allure is tainted by its decomposition. These issues are avoided by using a solvent-casting technique on a mercury surface in PXM matrix-type transdermal patches. In HPMC E50LV and Eudragit RS 100 transdermal patches, glycerine (plasticizer) is produced through solvent evaporation and a film-forming polymer. The FTIR method will be used aesthetics, breadth, weight difference, folding durability, moisture content, tensile strength, and percentage of PXM content were all deemed satisfactory on a physical level. According to the study, PXM release from transdermal patches can be improved by combining HPMC E50LV (400 mg) and Eudragit RS 100 (300 mg) with glycerine as a plasticize

To investigate the effect of Aluminium chloride on the activities of testicular enzymes in rat. Forty male Albino rats were divided into four groups (n=10). Treatment was given for a period of 45 days daily. Group-I Control given only distilled water, Group-II treated with aluminium chloride 50 mg/Kg body wt. Group-III treated with Vitamin E 20mg/Kg body weight. Group-IV treated with aluminium chloride+ Vitamin-E. The animals were sacrificed after 24 hours duration. Biochemical studies were observed in testis. Marker enzymes ALP, ACP and LDH, SDH activities were decreased significantly with control. Lipid peroxidation was increased significantly in aluminium chloride treated rats. The administration of AlCl3+Vit E shows protective effect from the toxicity.

E. littorale (Chota-kirayat or Chota–chirayata) is a glabrous perennial herb belongs to family Gentianaceae. It is traditionally used as antidiabetic, urinary astringent, antiperiodic, anthelmintic, anti-inflammatory, laxative and carminative. It possesses antioxidant, antimicrobial, antiedematologinic. antitumour activities. The present study deals with the pharmacognostical evaluation of Enicostemma litorale Blume. The physicochemical parameters like ash and extractive values were determined. The fluorescence analysis was observed both under ordinary light and UV light. The phytochemical analysis on extract was done by using different solvents and revealed the presence of steroids, terpenoids, alkaloids, phenolic compound, quinine, flavanoid, Tannin and Amino acid and identified by the basis of IR and gas chromatography-MS. The results of this study could be useful in setting some diagnostic indices for identification and preparation of the monograph of the plant.