IR

A series of novel N-(substituted)-2-[4-oxo-2-phenylquinazolin-3(4H)-yl] acetohydrazide derivatives were designed and synthesized, and their structures were characterized by 1H, 13C NMR, IR and Mass Spectral analysis. Their antimicrobial activity against bacterial strains and unicellular and multicellular pathogenic fungal strains were evaluated, and the results of in vitro antimicrobial evaluations of all newly synthesized compounds revealed that compounds 4(a-g) found to possess varied degree of antibacterial and antifungal activities Therefore, it can be inferred that presence of Schiff base nucleus in newly synthesized compounds can act as better system for antimicrobial activity. Lipinski rule were evident that all synthesized compounds have a good potential for development as an oral agent and can be potentially active drug candidate.

E. littorale (Chota-kirayat or Chota–chirayata) is a glabrous perennial herb belongs to family Gentianaceae. It is traditionally used as antidiabetic, urinary astringent, antiperiodic, anthelmintic, anti-inflammatory, laxative and carminative. It possesses antioxidant, antimicrobial, antiedematologinic. antitumour activities. The present study deals with the pharmacognostical evaluation of Enicostemma litorale Blume. The physicochemical parameters like ash and extractive values were determined. The fluorescence analysis was observed both under ordinary light and UV light. The phytochemical analysis on extract was done by using different solvents and revealed the presence of steroids, terpenoids, alkaloids, phenolic compound, quinine, flavanoid, Tannin and Amino acid and identified by the basis of IR and gas chromatography-MS. The results of this study could be useful in setting some diagnostic indices for identification and preparation of the monograph of the plant.