Santosh Dattu Navale

The triazoles possess wide spectrum of biological activities like including antibacterial, antifungal, antiviral, anti-inflammatory, anticonvulsant, antidepressant, antihypertensive, analgesic, and hypoglycemic properties. The present reviews attempted to gather the basic developments in synthesis and biological activities of triazole derivatives. The novel chemical moiety used in medicinal active substance either (R) or (L) hence Dextro or Levo rotatory form. The broad spectrum of activity is due nitrogen hence nitrogen containing loan pair of electron transfer to another substance and formation of covalent bond.

Nasal drug delivery system offers way of drug delivery of both topical and systemic therapies. The high permeability, high vasculature and low enzymatic environment of nasal cavity are well suitable for systemic delivery of drug molecules via nose. The despite of all the advantages of nasal drug delivery, the bioavailability of nasally administered products, especially for protein and peptide molecules, is affected by many barriers such as physiological barriers, physicochemical barriers, and formulation barriers. This review will focus on the various bioavailability barriers in nasal drug delivery and the strategies to improve the bioavailability of nasal dosage form

In the pharmaceutical industry the course is designed to give you the skills that have taken many experienced The New Drug Application (NDA) is an application submitted to U.S.FDA for permission to market a new drug product in the United States. The New Drug Application (NDA) is an application submitted to U.S.FDA for permission to market a new drug product in the United States. The components of any NDA are a function of the nature of the subject drug and the information available to the applicant at the time of submission. The form to use for either NDA or ANDA is Form FDA-356h, Application to Market a New Drug for Human Use or as an Antibiotic Drug for Human Use. The international regulatory authorities under consideration are WHO, USFDA, MHRA, and Australian TGA. The standard institutions give the economical background for development and transferring technologies, ISI, ISO, BISS and ASTM. To legally gather this data on safety and effectiveness in the U.S., the maker must first obtain an Investigational New Drug (IND) designation from FDA.

This experiment, first developed for a NSF Novel Process Workshop, is a highly visual experiment in chemical engineering processes and experimentation. In addition, it the coating process is environmentally benign because it has essentially no volatile emissions. The object of the experiment is to place a protective coating on a pellets, tablets, and metal object. The metal object is coated by first heating in a hot air stream and then dipping the object into a fluidized bed of thermoplastic powder. This experiment can be used throughout the curriculum.  For recruitment at the precollege and freshman level the fluid motion of the gas and particles can be observed through the clear plastic walls of the fluidized bed.  Using brightly colored particles gives the fluid bed the look of an executive desk amusement.  Prospective students and freshman can also feel the water like quality of the bed using a rod or ruler.  Freshmen use the fluidized bed as an example of the engineering measurements of flow rate, temperature, pressure and coating thickness.  They design an experiment to determine the desired coating thickness by varying the dipping time and temperature of the object.

To improve the solubility enhancement of solid dispersion of Lopinavir by spray-drying by adding the Soluplus as polymer that is compatible with Lopinavir, was evaluated and the process used for preparation of Spray dried solid dispersion was validated and the 1:3 ratio used for preparation of solid dispersion. Dissolution tests were carried out on several spray dried solid dispersion of Lopinavir and physical mixture. The solid dispersion characterized by DSC, XRD, % Entrapment Efficiency, solubility study, drug content determination, practical yield, dissolution studies.

In the pharmaceutical industry the course is designed to give you the skills that have taken many experienced auditors decades to develop. It follows the auditing guidance of ISO-19011 and is a virtual audit of a manufacturing facility that makes a range of dosage forms. This allows you to plan and prepare audits of the supplier and your own supplier audit system. Throughout the course, there is personal practice with exercises and teamwork’s in planning, preparation and performance that address WHO. The extensive of course notes and excellent lectures given by knowledgeable and professional tutors in pharmaceutical industry, The WHO was very easy to approach with any problems in during the course. The purpose of regulatory authorities to assess application for authorization to market products for human use and either grant authorizations to market each product or reject such applications and inspect the manufacturers and wholesalers of medicines for human use and either grant manufacturing and wholesale licenses or refuse such licenses. The international regulatory authorities under consideration are in this article WHO, USFDA, MHRA, and Australian TGA. The standard institutions give the economical background for development and transferring technologies, ISI, ISO, BISS and ASTM. 

The long circulatory liposome means shows action towards target organ longer period of time. Liposome are the concentric bilayer in which aqueous volume entirely envelope by the lipid bilayer used to transfer enzymes, protein and drugs to targets cancer cell or tissue. These are chemical moieties in which action towards target organ. It was first discovered by 1965 and soon was proposed drug delivery system. There are numerous application like anti fungal, anti cancer, anti inflammatory and anesthetic drugs. The magic bullet concept of Poul-Ehrlich et al; through very late, offers a logical solution to the age old problem unrelated and unwanted effect of therapeutic agent and optimizing the drug therapy in its true sense. The controlled, sustained and controlled drug delivery can be considered as the magic bullet concept. The long circulatory liposome gives the stealth effect called as killer bomber to cancer cell and arrest the Mitosis of M-phase and G-phase.

In the pharmaceutical industry an impurity is considered, defined the any other organic material besides the drug substance or pharmaceutical ingredients.  The impurity may be formed during the formulation or upon aging of two APIs in medicines. Stability testing is an integral part of pharmaceutical development. The primary purpose of stability testing is to provide supporting evidence on stability behavior of pharmaceutical drug products. Stability is the capacity of a drug product to remain within specifications established to ensure its identity, strength, quality and purity.

In the pharmaceutical industry an impurity is considered, defined the any other organic material besides the drug substance or pharmaceutical ingredients.  The impurity may be formed during the formulation or upon aging of two APIs in medicines. The highly sophisticated instrumentation, such as mass spectra meters attached to the gas chromatography or HPLC in various matrices. GC is the most useful technique for identification of residual solvent. The advent of hyphenated technique has revolution any impurity profiling, by not only separation but structural identification of impurities as well among all techniques. The most exploited techniques for impurities profiling of drug are LC-MS-MS, LC-NMR, LC-NMR-MS, GC-MS AND LC-MS.

The purpose of this article brings out the fabrication and recent clinical research in osmotic drug delivery system. The technology of osmotic drug delivery system need to be modified for the conventionally control over their release and almost control the safe and effective concentration in the targeted sites. The certain phenomenon of molecule may have low bioavailability hence to be improve by the fabrication osmotic drug delivery system is most promising system for controlled drug delivery system. The pump and technique most is used to developed the research point of view. The number of marketed oral osmotically driven system (OCDDS) has doubled in the last 11 years. The osmotic pressure utilized for osmotic drug delivery system (OCDDS).