Santosh Dattu Navale

Liposome proved themselves as a promising novel delivery vehicle of drugs to the skin, is a topic of considerable current interest. Liposomes are acceptable and superior carriers having ability to encapsulate both hydrophilic and lipophilic drugs and protect them from degradation. Liposomes are result of self-assembly of phospholipid in an aqueous media resulting in closed bilayer structures. Liposomes are one of unique drug delivery system which can be used in controlling and targeting drug delivery system. Liposomes are generally classified based upon structure, method of preparation, composition and application, conventional liposome, and specialty liposome. Different marketed formulations are available in market for liposomes. The liposomes have many applications which increase its importance over other formulations. The entrapped compound’s solubility and partitioning characteristics will determine its location in the liposomal bilayer .It also has affinity to keratin of horny layer of skin and can penetrate deeper into skin hence give better absorption. But they may also have the property into the skin, carrying actives to the target site, where these molecules will be released. Reformulation of drugs in liposomes has provided an opportunity to enhance the therapeutic indices of various agents. This review discusses the potential advantages in topical drug delivery, basic structure characteristics and mechanism of action of liposomes and evaluation parameter for liposome formulation.

Liposome are the concentric bilayer means core of center in which aqueous volume entirely envelope by the phospholipids bilayer used to transfer enzymes, protein and drugs to targets cancer cell or tissue. These are chemical moieties in which action towards target organ. It was first discovered by 1965 and soon was proposed drug delivery system. There are numerous application like anti fungal, anti cancer, anti inflammatory and anesthetic drugs. The magic bullet concept of Paul Ehrlich through very late, offers a logical solution to the age old problem unrelated and unwanted effect of therapeutic agent and optimizing the drug therapy in its true sense. Drugs would be targeted by virtue of groups having affinity for specific cells, tissues or organs. Liposome having also its modifications or upgraded versions likes enzymosomes, hemosomes, virosomes, and erythrosomes. Liposome has emerged as a dynamic mode for targeted drug delivery. Ligands confer specificity on a non specific reagent. Although controlled and sustained drug delivery can be considered as the magic bullet concept. We can look forward to many more clinical products in the future.