acetone

Heteroacyclic and Heterocyclic containing drugs showed remarkable and noticeable drug absorption, transmission and drug effects; hence they created their own identity and importance in pharmaceutical, medicinal, agricultural and drug sciences. Benzonido and pyridino, dithiazolo, quinolino and alkylamino heterocycles showed important applications in industrial, pharmaceutical, medicinal and drug chemistry.  Considering all these facts into consideration recently in this laboratory interaction of N-(7-chloroquinoline-4-yl)-N,N-diethyl-pentane-1,4-diamine (1) was carried out with thiourea (2) in ethanol medium to isolate N-(7-thiocarbamidoquinoline-4-yl)-N,N-diethyl-pentane-1,4-diamines (3). N-(7-thiocarbamido quinoline-4-yl)-N,N-diethyl-pentane-1,4-diamines on further interactions with various isothiocynates (4) in acetone-ethanol medium produces N-[7-(1- substituted) -2,4-dithiobiureto)-4-yl]-N,N-diethyl-pentane-1,4-diamine (5) which were successfully  oxidatively cyclised into N-[7-(5-substitutedimino-3-amino)-1,2,4-dithiazo-4-yl]-N,N-diethyl-pentane-1,4-diamine (6) these reactions are hither to unknown. The justification and identification of the structure of these newly synthesized compounds had been established on the basis of chemical characterization, elemental analysis and through spectral data.

The aim of the present study was to investigate the chemical composition of Spirulina subjected to different solvent extraction (acetone, methanol and ethyl acetate) by using soxhlet methodology and the extracts were analysis by Gas chromatography coupled with mass spectrophotometer (GC-MS) using DB-5 capillary column. During GC-MS analysis, it was observed that fatty acid components are present in their extracts. In acetone extract, totally forty compounds were identified and heptacosane (17.25%), hexacosane (17.04%), heneicosane (14.47%), pentacosane (13.22%) and Nonacosane (11.29%) as major components. Thirty five compounds were identified in methanol extract and the major compounds are n-Hexadecanoic acid (19.9%), Cyclononasiloxane octadeca methyl (7.81%) and phytol (6.53%). Thirty components were identified in ethyl acetate extract and dodecane (17.35%), heptadecane (15.31%), sufurous acid butyl heptadecyl ester (11.31%) and n-hexadecanoic acid (4.26%) most abundant in ethyl acetate extract.