Solvent casting

The objective of present study was to prepare and evaluate orally fast dissolving film of Esomeprazole magnesium trihydrate for the effective management of peptic ulcers to prevent excess amount of acid secretion in the stomach. Drug Esomeprazole was identified using DSC, FTIR and XRD. To improve the water solubility beta cyclodextrin complex of drug in 1:1 milimolar ratio was prepared. Solubility of drug in complex was found to be 7.67±0.52 mg/ml, represents the complex formation between drug and beta cyclodextrin. 21 batches of fast dissolving film of beta cyclodextrin complex were prepared by using different type of film forming agent, different concentration of film forming agent, different type of plasticizers, and different concentration of plasticizer agent. On evaluation, HPMC E15 and propylene glycol was optimized. Most of the films were homogeneous, transparent, colorless, flexible and easily peel out. The prepared films were subjected to characterization for weight variations, thickness, disintegration time, dissolving time, drug release pattern, % moisture loss etc.  On drug release kinetic mode study, optimized fast dissolving film following Higuchi model.  The scanning electron photomicrograph of the film showed smooth surface with some little pores and without any scratches or transverse striations which is an indication of uniform distribution of drug particles and fast disintegration. Films were stored at different temperature did not show any changes in the physical appearance. Clear, transparent and homogeneous films remained throughout the 90 days but at accelerated temperature conditions, some part of film was breakdown during Peeling out.

The present experimental study involves the preparation and characterization of  Orodispersible film of enalapril maleate. In this method HPMCK100 and propylene glycol are used to formulate orodispersible film and two disintegrating agent was used by using solvent casting method. Enalapril maleate is a antihypertensive drug which class of ACE inhibitor (Angiotensin converting enzyme). It is used in the treatment of hypertension congestive heart failure. It show low bioavailability due to high hepatic first pass metabolism so the soft palate drug delivery provide an excellent route to deliver the drug into systemic circulation and the present experimental work to formulate bioadhesive orodispersible of  enalapril maleate to improve the therapeutic efficacy, patient compliance and its bioavailability by avoiding the first pass metabolism. After proper preformulation studies various orodispersible film which were prepared subjected for several evaluation study like thickness, weight uniformity, surface pH, drug uniformity, folding endurance, In vitro disintegration time the drug is rapidly disintegrate within seconds. It means it show that best for the those patient who have difficult to swallowing the drug and .Invitro dissolution  study of prepared orodispersible film was carried out in phosphate buffer 7.4 as a medium and it was clearly observed that the F6 formulation  a best formulation because it rapidly drug release. All the formulation provide a well controlled drug release at a sustainable rate. From the experimental result it was clearly concluded that orodispersible film of enalapril maleate may use as an effective drug delivery with an enhance bioavailability.

Valacyclovir hydrochloride  is widely used for the treatment on Herpes virus, illness caused by Herpes virus such as Genital herpes, Cold sores, Chingles and Chicken pox. The present study is deals with formulation, optimization, evaluation of Valcyclovir HCL mouth dissolving films. Genital herpes, Cold sores, Chingles and Chicken pox are the conditions where instance effect of drug is required. Valacyclovir hydrochloride is one of the drug which is used in the treatment of above three disease conditions. The mouth dissolving films was prepared by using solvent casting method. The concentration of propylene glycol, sodium lauryl sulphate (SLS) were kept constant in all formulations (F1-F4) and varying concentration of hydroxy propyl methyl cellulose(HPMC) and methyl cellulose. All the formulations were evaluated for surface pH, weight uniformity, folding endurance, drug content, disintegration time, in-vitro dissolution studies. The formulation ‘F3’ was found to be optimized formulation. It shows results for all evaluation parameters such as weight variation 34.70±0.7mg, surface pH 6.75±0.60, folding endurance > 100, drug content 95.25±1.10%, disintegration time 30±0.50 sec, and in-vitro dissolution study 81.35±1.30 % at the end of 5 min.

Oral drug delivery is the most widely used and acceptable drug delivery amongst the other delivery. The orally disintegrating tablets are available in the market providing one to two minute of disintegration time. Among fast dissolving drug delivery systems, oral strip (OST) drug delivery system is an alternative to tablets, capsules, and syrups for paediatric and geriatric patients who experience in difficulties of swallowing traditional oral solid dosage forms. This technology has been used for local action, rapid release of products and for direct systemic circulation in the oral cavity to release drug in rapid fashion. And also this delivery protect drug from first pass metabolism and improve the dissolution. The main attention towards OST review article is providing knowledge of materials used in OST, critical manufacturing aspects, applications, commercial technologies.