Crosspovidone

The purpose of this study is to prepare Mouth dissolving tablets of Cinnarizine HCl and Domperidone Maleate by Direct compression method. In the present research study, Crosspovidone (CP) and Sodium Starch Glycolate (SSG) was taken as super disintegrant. Here the Cinnarizine HCl (H1 anti-histaminics) and Domperidone (anti-emetic) is taken as the model drug for the study and direct compression as a method for preparation of the Mouth Dissolving Tablet. These combination of drugs are ideal for the prevention of symptoms caused by vestibular disorders and vertigo/motion sickness, nausea, dizziness, headache, vomiting, sensation of fullness when there is a delay in gastric emptying. A 32 full factorial design was applied to investigate the combine effect of two formulation variable CP(X1) and SSG(X2). Here the concentration of both Superdisintegrants was taken as independent variable, X1 and X2 respectively. I.R. and DSC study revealed that all polymers and excipients used were compatible with the drugs. All the pre and post-compression evaluation parameters shows good results and all batches are within acceptable limits. Mouths feel test gives pleasant sensation on human subjects when tablets are put it on tongue. The effect of Disintegration time (Y1) and % Drug release (Y2) were investigated as dependent parameters. From optimization data results that, among all the formulation F6 Batch was best formulation. The optimized batch obtained from the factorial design was compared with the marketed products. The stability study of the optimized batch is also done at 40ºC and 75%RH.

The present experimental study involves the preparation and characterization of  Orodispersible film of enalapril maleate. In this method HPMCK100 and propylene glycol are used to formulate orodispersible film and two disintegrating agent was used by using solvent casting method. Enalapril maleate is a antihypertensive drug which class of ACE inhibitor (Angiotensin converting enzyme). It is used in the treatment of hypertension congestive heart failure. It show low bioavailability due to high hepatic first pass metabolism so the soft palate drug delivery provide an excellent route to deliver the drug into systemic circulation and the present experimental work to formulate bioadhesive orodispersible of  enalapril maleate to improve the therapeutic efficacy, patient compliance and its bioavailability by avoiding the first pass metabolism. After proper preformulation studies various orodispersible film which were prepared subjected for several evaluation study like thickness, weight uniformity, surface pH, drug uniformity, folding endurance, In vitro disintegration time the drug is rapidly disintegrate within seconds. It means it show that best for the those patient who have difficult to swallowing the drug and .Invitro dissolution  study of prepared orodispersible film was carried out in phosphate buffer 7.4 as a medium and it was clearly observed that the F6 formulation  a best formulation because it rapidly drug release. All the formulation provide a well controlled drug release at a sustainable rate. From the experimental result it was clearly concluded that orodispersible film of enalapril maleate may use as an effective drug delivery with an enhance bioavailability.