Disintegration time

The purpose of this study is to prepare Mouth dissolving tablets of Cinnarizine HCl and Domperidone Maleate by Direct compression method. In the present research study, Crosspovidone (CP) and Sodium Starch Glycolate (SSG) was taken as super disintegrant. Here the Cinnarizine HCl (H1 anti-histaminics) and Domperidone (anti-emetic) is taken as the model drug for the study and direct compression as a method for preparation of the Mouth Dissolving Tablet. These combination of drugs are ideal for the prevention of symptoms caused by vestibular disorders and vertigo/motion sickness, nausea, dizziness, headache, vomiting, sensation of fullness when there is a delay in gastric emptying. A 32 full factorial design was applied to investigate the combine effect of two formulation variable CP(X1) and SSG(X2). Here the concentration of both Superdisintegrants was taken as independent variable, X1 and X2 respectively. I.R. and DSC study revealed that all polymers and excipients used were compatible with the drugs. All the pre and post-compression evaluation parameters shows good results and all batches are within acceptable limits. Mouths feel test gives pleasant sensation on human subjects when tablets are put it on tongue. The effect of Disintegration time (Y1) and % Drug release (Y2) were investigated as dependent parameters. From optimization data results that, among all the formulation F6 Batch was best formulation. The optimized batch obtained from the factorial design was compared with the marketed products. The stability study of the optimized batch is also done at 40ºC and 75%RH.

Oral drug delivery has been known for decades as the most widely utilized route of administration among all the routes. United State Food and Drug Administration (FDA) defined ODT as “a solid dosage form containing medicinal substance or active ingredients which disintegrate rapidly usually within a matter of second when placed upon the tongue. Propranolol is a nonselective beta-adrenergic blocker and is almost completely absorbed following oral administration. However , most of drug is undergoes high first-pass metabolism by the liver and on average, only about 25% of propranolol reaches the systemic circulation. The present study investigated to development of novel fast dissolving tablet of Propranolol HCL which was by first pass metabolism, provide rapid onset of action and increasing the bioavailability of the drug. The fast dissolving tablets were prepared by Direct compression method by using different superdisintegrant like Crosspovidone, crosscarmellose sodium, sodium starch glycolate etc. The advantage of this formulation is such that in case of hypertension attack patient can take the drug without the usage of water. Therefore the main objective of the present work is to develop orodispersible tablets of Propranolol hydrochloride to improve bioavailability, disintegration time, dissolution efficacy and patient compliance.

Oral drug delivery is the most widely used and acceptable drug delivery amongst the other delivery. The orally disintegrating tablets are available in the market providing one to two minute of disintegration time. Among fast dissolving drug delivery systems, oral strip (OST) drug delivery system is an alternative to tablets, capsules, and syrups for paediatric and geriatric patients who experience in difficulties of swallowing traditional oral solid dosage forms. This technology has been used for local action, rapid release of products and for direct systemic circulation in the oral cavity to release drug in rapid fashion. And also this delivery protect drug from first pass metabolism and improve the dissolution. The main attention towards OST review article is providing knowledge of materials used in OST, critical manufacturing aspects, applications, commercial technologies.