Direct compression

Liquisolid technique is a new approach for delivery of drugs through oral cavity. This technique is suitable for poorly or water insoluble drugs and also for immediate or sustained release formulations. The technique is based upon the admixture of drug loaded solutions or liquid drug with appropriate carrier and coating materials to convert into acceptably flowing and compressible powder. The selection of non-toxic hydrophilic solvent, carrier, coating excipients and its ratios are independent of the individual chemical entities. Indirectly its leads to enhancement of bioavailibity. Liquisolid tablet of drug Tacrolimus were prepared by using PG, PEG 200, PEG 400, glycerin, Tween 80 and Span 80, as non volatile liquid vehicle, respectively. Tacrolimus is an immunosuppressive drug, which have poor water solubility and low bioavailability, so it is suitable for liquisolid technique. Also Tacrolimus is having daily dose 5-10 mg once a daily. FTIR and DSC studies reveal that there was no possible interaction between drug and tablet excipients. All the formulation was evaluated for disintegration time, hardness and friability time, in-vitro dissolution study.

Candesartan cilexetil is an antihypertensive drug effective for the treatment of hypertension and heart failure. The main goal is to formulate and evaluate the sustained release matrix tablets of candesartan cilexetil using different polymers like hydrophilic and hydrophobic. Different formulations were prepared by direct compression method using various release retarding polymers like carbopol 934P, HPMC K15M, sod.CMC. Water soluble surfactant SLS was employed for enhancing the solubility of candesartan cilexetil. Drug-excipients compatibility was carried out by FTIR. Different formulations were evaluated for hardness, thickness, friability, drug content and in vitro drug release. The results were found to be satisfactory in terms of physico-chemical parameters. The F10 formulation was found to display highest drug release of drug. Mathematical analysis of the release kinetics was carried out to determine the mechanism of drug release. In vitro release data was fitted into various models to ascertain the kinetic of drug release.

Oral drug delivery has been known for decades as the most widely utilized route of administration among all the routes. United State Food and Drug Administration (FDA) defined ODT as “a solid dosage form containing medicinal substance or active ingredients which disintegrate rapidly usually within a matter of second when placed upon the tongue. Propranolol is a nonselective beta-adrenergic blocker and is almost completely absorbed following oral administration. However , most of drug is undergoes high first-pass metabolism by the liver and on average, only about 25% of propranolol reaches the systemic circulation. The present study investigated to development of novel fast dissolving tablet of Propranolol HCL which was by first pass metabolism, provide rapid onset of action and increasing the bioavailability of the drug. The fast dissolving tablets were prepared by Direct compression method by using different superdisintegrant like Crosspovidone, crosscarmellose sodium, sodium starch glycolate etc. The advantage of this formulation is such that in case of hypertension attack patient can take the drug without the usage of water. Therefore the main objective of the present work is to develop orodispersible tablets of Propranolol hydrochloride to improve bioavailability, disintegration time, dissolution efficacy and patient compliance.

The idea of formulation of controlled release drug delivery has become beneficial in the treatment of diseases. At this time, the increased understanding in the community and the significance of safe use of drugs encouraged to develop novel drug delivery system. In the present study, an attempt was made to expand the release of Cefpodoxime proxetil from matrix tablets by sintering technique. This has been an evolving one in the study of effect of heating on mechanical properties of pharmaceutical powders that is used in the formulation of sustained release matrix tablet. The tablets were formulated by direct compression method. The punched tablets were subjected to sintering process and exposed to three different durations of sintering (1.5, 3.0 and 4.5 hours). This type of system provides a important and suitable method for achieving controlled release in oral dosage forms. The release of the drug form un-sintered matrix tablets containing 100 mg polymer was 100% within 90 minutes. For a particular sintering time, the release rate decreased with increasing polymer concentration. For 1.5, 3.0, and 4.5 hours sintering durations the least retardation is offered by least polymer concentration. The highest retardation was offered by matrices with highest polymer concentration.