Cefpodoxime proxetil

The idea of formulation of controlled release drug delivery has become beneficial in the treatment of diseases. At this time, the increased understanding in the community and the significance of safe use of drugs encouraged to develop novel drug delivery system. In the present study, an attempt was made to expand the release of Cefpodoxime proxetil from matrix tablets by sintering technique. This has been an evolving one in the study of effect of heating on mechanical properties of pharmaceutical powders that is used in the formulation of sustained release matrix tablet. The tablets were formulated by direct compression method. The punched tablets were subjected to sintering process and exposed to three different durations of sintering (1.5, 3.0 and 4.5 hours). This type of system provides a important and suitable method for achieving controlled release in oral dosage forms. The release of the drug form un-sintered matrix tablets containing 100 mg polymer was 100% within 90 minutes. For a particular sintering time, the release rate decreased with increasing polymer concentration. For 1.5, 3.0, and 4.5 hours sintering durations the least retardation is offered by least polymer concentration. The highest retardation was offered by matrices with highest polymer concentration.

The present manuscript describe simple, sensitive, rapid, accurate, precise and economical Q-absorbance ratio method for the simultaneous determination of Cefpodoxime proxetil and ofloxacin in combined tablet dosage form. Absorbance ratio method uses the ratio of absorbances at two selected wavelengths, one which is an isoabsorptive point and other being the λ-max of one of the two components. Cefpodoxime proxetil and ofloxacin show an isoabsorptive point at 272 nm in methanol. The second wavelength used is 236 nm, which is the λ-max of Cefpodoxime proxetil in methanol. The linearity was obtained in the concentration range of 5-17 μg/ml for both Cefpodoxime proxetil and Ofloxacin. The concentrations of the drugs were determined by using ratio of absorbances at isoabsorptive point and at the λ-max of ofloxacin. The method was successfully applied to pharmaceutical dosage form because no interference from the tablet excipients was found. The results of analysis have been validated statistically and by recovery studies. Key Words: Cefpodoxime proxetil, Ofloxacin, Absorption ratio method Tablets, Validation.  

  The present manuscript describe simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of Ofloxacin and Cefpodoxime proxetil in combined tablet dosage form. The method is based on the simultaneous equations for analysis of both the drugs using methanol as solvent. Ofloxacin has absorbance maxima at 297 nm and cefpodoxime proxetil has absorbance maxima at 236.2 nm in methanol. The linearity was obtained in the concentration range of 2-12 μg/ml and 4-24 μg/ml for Ofloxacin and Cefpodoxime proxetil, respectively. The concentrations of the drugs were determined by using simultaneous equations at both the wavelengths. The mean recovery was 99.63 ± 0.47 and 99.57 ± 0.36 for Ofloxacin and Cefpodoxime proxetil, respectively. The method was successfully applied to pharmaceutical dosage form because no interference from the tablet excipients was found. The suitability of this method for the quantitative determination of Ofloxacin and Cefpodoxime proxetil was proved by validation. The proposed method was found to be simple and sensitive for the routine quality control application of Ofloxacin and Cefpodoxime proxetil in pharmaceutical tablet dosage form. The results of analysis have been validated statistically and by recovery studies.   Key words: Cefpodoxime proxetil, Ofloxacin, recovery, simultaneous equations method, tablet, validation.