sodium CMC

Candesartan cilexetil is an antihypertensive drug effective for the treatment of hypertension and heart failure. The main goal is to formulate and evaluate the sustained release matrix tablets of candesartan cilexetil using different polymers like hydrophilic and hydrophobic. Different formulations were prepared by direct compression method using various release retarding polymers like carbopol 934P, HPMC K15M, sod.CMC. Water soluble surfactant SLS was employed for enhancing the solubility of candesartan cilexetil. Drug-excipients compatibility was carried out by FTIR. Different formulations were evaluated for hardness, thickness, friability, drug content and in vitro drug release. The results were found to be satisfactory in terms of physico-chemical parameters. The F10 formulation was found to display highest drug release of drug. Mathematical analysis of the release kinetics was carried out to determine the mechanism of drug release. In vitro release data was fitted into various models to ascertain the kinetic of drug release.

For the evaluation of the wound healing activity polymer composite films were prepared by using Chitosan and in combination with Sodium CMC with and without glutaraldehyde were prepared by solvent casting method. Mupirocin was incorporated into selected polymeric films. All the polymeric composite films were characterized by IR study suggested that there was no chemical reaction has taken place, only ionic complexes were formed. All the films were evaluated for thickness, folding endurance and tensile strength. The thickness of all the films was uniform,The folding endurance suggested good flexibility of the films as propylene glycol was used as a plasticizer, Films shown good tensile strength  necessary for better handling . The water vapour penetration suggested that films without cross linker absorbs more moisture compared to films containing cross linking agent. The presence of cross linking agent shown optimum bio-adhesion. All the polymer composite films were evaluated for in vitro swelling study. The films showed good swelling in water more than 6 hrs retaining the shape of the films. The addition of cross linking agent decreased the swelling. Selected polymer composite films were evaluated for in vivo wound healing activity. All the polymeric films showed more than 80% reduction in wound contraction. The mupirocin loaded polymeric composite containing Sodium CMC, shown more than 95% of reduction in wound area after 12 day. Hence it can be concluded that polymer composite films of chitosan-alginate containing mupirocin along with Sodium CMC showed good wound healing and could be used in effective management of wound.