Fast dissolving film

The major problem in formulation of oral films of cilnidipine is that it belongs to BCS Class II moiety. Pharmacologically Cilnidipine is a dihydropyridine (DHP) type of calcium channel antagonist. Unlike other calcium channel antagonists, Cilnidipine blocks the influx of Ca2+ ions into both vascular smooth muscle at the level of L-type Ca2+ channels and neuronal cells at the level of N-type Ca2+ channels. Cilnidipine was absorbed over 2 hours and its bioavailability is 64-90%. Hence there is a need to increase the solubility and oral bioavailability of cilnidipine by formulating it in to solid dispersions and incorporating the same in to the formulation of fast dissolving films which gives fast onset of action. Nine formulations (FC 1 - FC 9) of cilnidipine films were prepared and evaluated for their physical characteristics such as thickness, weight variation, folding endurance, drug content uniformity and gave satisfactory results. The compatibility of the drug in the formulation was confirmed by FTIR and DSC studies. The formulations were subjected to disintegration, in vitro drug release studies and formulation FC 6 was found to be best formulation which contain HPMC, PVP as film forming polymers along with cilnidipine solid dispersion with poly ethylene glycol at weight ratio of 1:4 showed excellent film forming characteristics such as disintegration time of 49.3 sec and percentage drug release 97.92 within 8 minutes.

Oral route is still the preferred route of drug administration for majority of the population as it is non invasive and convenient but has some inherited flaws as certain patients like young children and geriatric patients have difficulty in swallowing. Recent trends are shifting toward design and development of a novel carrier system for existing drugs. Oral disintegrating films (ODF) play an eminent role, as it dissolves rapidly in the mouth and reaches directly into systemic circulation. Various methods have been used for formulating ODF, among which solvent casting is frequently used. The film consists of generally both hydrophilic and hydrophobic polymers and other suitable excipients which either dissolves or disperses rapidly in the oral cavity and releases the active ingredient. The present review is mainly focused on the formulation approaches, their evaluation and therapeutic benefits of ODF.

Valacyclovir hydrochloride  is widely used for the treatment on Herpes virus, illness caused by Herpes virus such as Genital herpes, Cold sores, Chingles and Chicken pox. The present study is deals with formulation, optimization, evaluation of Valcyclovir HCL mouth dissolving films. Genital herpes, Cold sores, Chingles and Chicken pox are the conditions where instance effect of drug is required. Valacyclovir hydrochloride is one of the drug which is used in the treatment of above three disease conditions. The mouth dissolving films was prepared by using solvent casting method. The concentration of propylene glycol, sodium lauryl sulphate (SLS) were kept constant in all formulations (F1-F4) and varying concentration of hydroxy propyl methyl cellulose(HPMC) and methyl cellulose. All the formulations were evaluated for surface pH, weight uniformity, folding endurance, drug content, disintegration time, in-vitro dissolution studies. The formulation ‘F3’ was found to be optimized formulation. It shows results for all evaluation parameters such as weight variation 34.70±0.7mg, surface pH 6.75±0.60, folding endurance > 100, drug content 95.25±1.10%, disintegration time 30±0.50 sec, and in-vitro dissolution study 81.35±1.30 % at the end of 5 min.