SGPT

HLA-B27 test is generally positive in spondyloarthritis (SpA) and ankylosing spondylitis (AS). Several anomalous laboratory test results are frequently found in HLA-B27-positive patients. In this study, we intended to evaluate two groups of HLA-B27 positive patients- one group belonging to the 13-40 years age group and another group belonging to the 41-71 years age group. The rationale of this partition was based on the age when AS first emerged and the age when the disease was set up for quite a few years respectively. We anticipate alterations of several familiar laboratory test outcomes between these two groups. After our analysis, we found that in the upper age group, ESR and uric acid are significantly decreased, while SGPT, creatinine, and HbA1C are significantly increased. Other values like ct value in PCR, RA seropositivity, and TC of WBC are decreased a bit in the higher age group; haemoglobin and CRP also marginally increased in this set which are not statistically significant. The plausible explanations behind these changes are discussed.

Objective of the present investigation is to evaluate the hepatoprotective activity of combine form of Phylanthus Niruli herbs and Solanum nigrum stem bark extracts against paracetamol-induced hepatotoxicity. Materials and methods: Hepatotoxicity was induced in male Wistar rats by oral solution of paracetamol (500mg/kg for 7 days). Aqueous extracts of combine form of Phylanthus Niruli herbs and Solanum nigrum stem bark were administered to the experimental rats (300 mg/kg/day, p.o. for 7 days). The hepatoprotective effect of these extracts was evaluated by the assay of liver function biochemical parameters (% of body weight changes, total bilirubin count, total protein, total cholesterol, HDL, SGPT and SGOT level) and histopathological studies of the liver. Results: In Aqueous extracts of combine form of Phylanthus Niruli herbs and Solanum nigrum stem bark extract-treated animals, the toxic effect of paracetamol  was controlled significantly by restoration of the levels of serum bilirubin, protein and enzymes as compared to the normal and the standard drug silymarin-treated groups. Histology of the liver sections of the animals treated with the extracts showed the presence of normal hepatic cords, absence of necrosis and fatty infiltration, which further evidenced the hepatoprotective activity. Conclusion: Aqueous extracts of combine form of Phylanthus Niruli herbs and Solanum nigrum stem bark possesses significant hepatoprotective activity. Key words: Hepatoprotective, SGPT, SGOT, HDL, Solanum nigrum, Phylanthus Niruli