ESR

HLA-B27 test is generally positive in spondyloarthritis (SpA) and ankylosing spondylitis (AS). Several anomalous laboratory test results are frequently found in HLA-B27-positive patients. In this study, we intended to evaluate two groups of HLA-B27 positive patients- one group belonging to the 13-40 years age group and another group belonging to the 41-71 years age group. The rationale of this partition was based on the age when AS first emerged and the age when the disease was set up for quite a few years respectively. We anticipate alterations of several familiar laboratory test outcomes between these two groups. After our analysis, we found that in the upper age group, ESR and uric acid are significantly decreased, while SGPT, creatinine, and HbA1C are significantly increased. Other values like ct value in PCR, RA seropositivity, and TC of WBC are decreased a bit in the higher age group; haemoglobin and CRP also marginally increased in this set which are not statistically significant. The plausible explanations behind these changes are discussed.

Studies carried out in the past have shown that in infectious diseases there is increase in the levels of Erythrocyte Sedimentation Rate (ESR), White Blood Corpuscles (WBC) and liver enzymes Alanine Aminotransferase (ALT), Gamma GlutamylTransferase (GGT) and Lactate Dehydrogenase (LDH).  There are other inflammatory markers like C reactive protein (CRP) and Procalcitonin, both of which are altered in several infectious diseases.  This study is an attempt to find out the correlation of ESR  to WBC and  several analytes of liver function tests such as  Aspartate aminotransferase (AST), ALT,  ALP,  GGT and  Albumin.  Results available for 100 patients attending the master health check up were used to find out the above associations. Very good correlations were observed between ESR and WBC for all patients (p