GGT

Breast cancer comprises a diverse collection of diseases rather than a single homogeneous disease. Both preclinical and clinical research now commonly target specific subgroups of breast cancer with the aim of identifying biological markers or genetic phenotypes, and to reveal subgroup-specific therapeutic targets or indicators of prognosis. Since genetics is believed to account for only 10% of the reported cases, the environmental factors including diet are thought to play a significant role in predisposing breast cancer. The present study was aimed to evaluate the chemotherapeutic potential of taurine in 7, 12-dimethyl Benz (a) anthracene (DMBA) induced mammary carcinoma in rats. Oral treatment of taurine (100 mg/kg BW) to breast tumor bearing rats daily for ten to fifteen weeks was found to be effective against DMBA induced mammary gland carcinogenesis in female Sprague Dawley rats. The increased activities of 5′-ND, GGT and LDH in tissue of control and experimental breast cancer rats were significantly (p 

Cypermethrin is synthetic pesticide that has been in use for more than a decade. A study of a low-dose exposure of this pesticide in rat administered, followed by determination of enzyme rate constant will highlight early catalytic changes that generally accompanied a toxic response in the animal. Even though, cypermethrin was used at 5 mM, for durations of 6, 12 and 24 h in the different groups of rats, results of the study indicate that simultaneous with changes in enzyme activity and rate constant of selected enzymes in selected tissues and serum. Tissue specific changes in the enzyme rate constant were suggestive of the lack of tissue resistance to pyrethroids.  Key words: Cypermethrin; ALT; AST; ALP; ACP; GGT